TY  - JOUR
AU  - Paunović, Milica G
AU  - Matić, Miloš M
AU  - Ognjanović, Branka I
AU  - Saičić, Zorica
PY  - 2017
UR  - http://journals.sagepub.com/doi/10.1177/0748233717725480
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28950793
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2889
AB  - Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q10 (CoQ10) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ10 and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ10 (20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group). After 24 h, Cd was injected intraperitoneally (0.4 mg/kg b.w.) and 1 day after, animals were sacrificed. Acute Cd intoxication caused significant changes in haematological and biochemical parameters and altered the glutathione cycle, leading to the formation of lipid peroxidation, while the concentrations and activities of antioxidants (vitamins C and E, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were decreased. CoQ10 and/or VE significantly maintained these values to near-normal levels, afforded additional protection by reducing lipid peroxidation and improved the levels of antioxidants in the blood. Plasma CoQ10 and VE levels negatively correlated with oxidative damage parameters while positively correlated with antioxidative defence parameters. Regarding their effects, CoQ10 and VE were in synergistic interaction. The present study suggested that CoQ10 and VE combination may be beneficial in protecting from Cd-induced haematotoxicity and may be used as a preventive against acute Cd intoxication of exposed people.
T2  - Toxicology and industrial health
T1  - Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats.
IS  - 10
VL  - 33
DO  - 10.1177/0748233717725480
SP  - 746
EP  - 756
ER  - 

@article{
author = "Paunović, Milica G and Matić, Miloš M and Ognjanović, Branka I and Saičić, Zorica",
year = "2017",
abstract = "Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q10 (CoQ10) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ10 and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ10 (20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group). After 24 h, Cd was injected intraperitoneally (0.4 mg/kg b.w.) and 1 day after, animals were sacrificed. Acute Cd intoxication caused significant changes in haematological and biochemical parameters and altered the glutathione cycle, leading to the formation of lipid peroxidation, while the concentrations and activities of antioxidants (vitamins C and E, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were decreased. CoQ10 and/or VE significantly maintained these values to near-normal levels, afforded additional protection by reducing lipid peroxidation and improved the levels of antioxidants in the blood. Plasma CoQ10 and VE levels negatively correlated with oxidative damage parameters while positively correlated with antioxidative defence parameters. Regarding their effects, CoQ10 and VE were in synergistic interaction. The present study suggested that CoQ10 and VE combination may be beneficial in protecting from Cd-induced haematotoxicity and may be used as a preventive against acute Cd intoxication of exposed people.",
journal = "Toxicology and industrial health",
title = "Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats.",
number = "10",
volume = "33",
doi = "10.1177/0748233717725480",
pages = "746-756"
}

Paunović, M. G., Matić, M. M., Ognjanović, B. I.,& Saičić, Z.. (2017). Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats.. in Toxicology and industrial health, 33(10), 746-756.
https://doi.org/10.1177/0748233717725480

Paunović MG, Matić MM, Ognjanović BI, Saičić Z. Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats.. in Toxicology and industrial health. 2017;33(10):746-756.
doi:10.1177/0748233717725480 .

Paunović, Milica G, Matić, Miloš M, Ognjanović, Branka I, Saičić, Zorica, "Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats." in Toxicology and industrial health, 33, no. 10 (2017):746-756,
https://doi.org/10.1177/0748233717725480 . .

TY  - CONF
AU  - Matić, Milos M
AU  - Paunović, M
AU  - Ognjanović, Branka I
AU  - Stajn, Andras S
AU  - Babić, Goran M
AU  - Saičić, Zorica
AU  - Đorđević, Natasa Z
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1144
C3  - Febs Journal
T1  - The effects of neuropeptide Y on oxidative/antioxidative status in trophoblasts
IS  - null
VL  - 279
SP  - 747
EP  - 221
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1144
ER  - 

@conference{
author = "Matić, Milos M and Paunović, M and Ognjanović, Branka I and Stajn, Andras S and Babić, Goran M and Saičić, Zorica and Đorđević, Natasa Z",
year = "2012",
journal = "Febs Journal",
title = "The effects of neuropeptide Y on oxidative/antioxidative status in trophoblasts",
number = "null",
volume = "279",
pages = "747-221",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1144"
}

Matić, M. M., Paunović, M., Ognjanović, B. I., Stajn, A. S., Babić, G. M., Saičić, Z.,& Đorđević, N. Z.. (2012). The effects of neuropeptide Y on oxidative/antioxidative status in trophoblasts. in Febs Journal, 279(null), 747-221.
https://hdl.handle.net/21.15107/rcub_ibiss_1144

Matić MM, Paunović M, Ognjanović BI, Stajn AS, Babić GM, Saičić Z, Đorđević NZ. The effects of neuropeptide Y on oxidative/antioxidative status in trophoblasts. in Febs Journal. 2012;279(null):747-221.
https://hdl.handle.net/21.15107/rcub_ibiss_1144 .

Matić, Milos M, Paunović, M, Ognjanović, Branka I, Stajn, Andras S, Babić, Goran M, Saičić, Zorica, Đorđević, Natasa Z, "The effects of neuropeptide Y on oxidative/antioxidative status in trophoblasts" in Febs Journal, 279, no. null (2012):747-221,
https://hdl.handle.net/21.15107/rcub_ibiss_1144 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Đorđević, Natasa Z
AU  - Matić, Milos M
AU  - Obradović, Jasmina M
AU  - Mladenović, Jelena M
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1209
AB  - Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage.
T2  - International Journal of Molecular Sciences
T1  - Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium
IS  - 2
VL  - 13
EP  - 1803
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1209
ER  - 

@article{
author = "Ognjanović, Branka I and Đorđević, Natasa Z and Matić, Milos M and Obradović, Jasmina M and Mladenović, Jelena M and Stajn, Andras S and Saičić, Zorica",
year = "2012",
abstract = "Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage.",
journal = "International Journal of Molecular Sciences",
title = "Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium",
number = "2",
volume = "13",
pages = "1803",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1209"
}

Ognjanović, B. I., Đorđević, N. Z., Matić, M. M., Obradović, J. M., Mladenović, J. M., Stajn, A. S.,& Saičić, Z.. (2012). Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium. in International Journal of Molecular Sciences, 13(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1209

Ognjanović BI, Đorđević NZ, Matić MM, Obradović JM, Mladenović JM, Stajn AS, Saičić Z. Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium. in International Journal of Molecular Sciences. 2012;13(2):null-1803.
https://hdl.handle.net/21.15107/rcub_ibiss_1209 .

Ognjanović, Branka I, Đorđević, Natasa Z, Matić, Milos M, Obradović, Jasmina M, Mladenović, Jelena M, Stajn, Andras S, Saičić, Zorica, "Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium" in International Journal of Molecular Sciences, 13, no. 2 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1209 .

TY  - JOUR
AU  - Marković, Snezana D
AU  - Zizić, Jovana B
AU  - Obradović, Ana D
AU  - Ognjanović, Branka I
AU  - Stajn, Andras S
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1287
AB  - Stimulated erythropoiesis and reticulocytosis can be induced by daily bleeding, or by phenylhydrazine (PHZ) treatment. We compared the in vivo effects of PHZ and bleeding treatment on haematological, energy and redox status parameters in red blood cells (RBC) of rats. The results showed that all followed haematological parameters were significantly lower in bleeding, compared to PHZ-treated rats. PHZ induced even 2.58-fold higher reticulocytosis as compared to bleeding treatment. Although PHZ induced higher reticulocytosis, respiration intensity and energy production was lower than in bleeding-induced reticulocytes. These alterations were the consequence of increased superoxide anion and peroxynitrite concentrations in PHZ-treated rats. Bleeding treatment resulted in increased activity of an antioxidative enzyme, superoxide dismutase. In conclusion, differences in these two experimental models for reticulocytosis may be used as tools for appropriate pharmacological testing of redox-active substances considering energy and redox processes, as well as apoptosis pathways.
T2  - Acta Biologica Hungarica
T1  - Energy Production and Redox Status of Rat Red Blood Cells After Reticulocytosis Induced By Various Treatments
IS  - 2
VL  - 62
EP  - 132
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1287
ER  - 

@article{
author = "Marković, Snezana D and Zizić, Jovana B and Obradović, Ana D and Ognjanović, Branka I and Stajn, Andras S and Saičić, Zorica and Spasić, Mihajlo",
year = "2011",
abstract = "Stimulated erythropoiesis and reticulocytosis can be induced by daily bleeding, or by phenylhydrazine (PHZ) treatment. We compared the in vivo effects of PHZ and bleeding treatment on haematological, energy and redox status parameters in red blood cells (RBC) of rats. The results showed that all followed haematological parameters were significantly lower in bleeding, compared to PHZ-treated rats. PHZ induced even 2.58-fold higher reticulocytosis as compared to bleeding treatment. Although PHZ induced higher reticulocytosis, respiration intensity and energy production was lower than in bleeding-induced reticulocytes. These alterations were the consequence of increased superoxide anion and peroxynitrite concentrations in PHZ-treated rats. Bleeding treatment resulted in increased activity of an antioxidative enzyme, superoxide dismutase. In conclusion, differences in these two experimental models for reticulocytosis may be used as tools for appropriate pharmacological testing of redox-active substances considering energy and redox processes, as well as apoptosis pathways.",
journal = "Acta Biologica Hungarica",
title = "Energy Production and Redox Status of Rat Red Blood Cells After Reticulocytosis Induced By Various Treatments",
number = "2",
volume = "62",
pages = "132",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1287"
}

Marković, S. D., Zizić, J. B., Obradović, A. D., Ognjanović, B. I., Stajn, A. S., Saičić, Z.,& Spasić, M.. (2011). Energy Production and Redox Status of Rat Red Blood Cells After Reticulocytosis Induced By Various Treatments. in Acta Biologica Hungarica, 62(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1287

Marković SD, Zizić JB, Obradović AD, Ognjanović BI, Stajn AS, Saičić Z, Spasić M. Energy Production and Redox Status of Rat Red Blood Cells After Reticulocytosis Induced By Various Treatments. in Acta Biologica Hungarica. 2011;62(2):null-132.
https://hdl.handle.net/21.15107/rcub_ibiss_1287 .

Marković, Snezana D, Zizić, Jovana B, Obradović, Ana D, Ognjanović, Branka I, Stajn, Andras S, Saičić, Zorica, Spasić, Mihajlo, "Energy Production and Redox Status of Rat Red Blood Cells After Reticulocytosis Induced By Various Treatments" in Acta Biologica Hungarica, 62, no. 2 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1287 .

TY  - JOUR
AU  - Đorđević, Natasa Z
AU  - Babić, Goran M
AU  - Marković, Snezana D
AU  - Ognjanović, Branka I
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1394
AB  - In the present study, we evaluated changes of both oxidative stress marker concentrations in erythrocytes and values of blood pressure, as well as their relation during short-term estradiol therapy in preeclampsia. Serum estradiol concentrations were also recorded. The results of this study showed significant decrease of mean arterial pressure (MAP) values during estradiol therapy, whereas there was no significant change in serum estradiol concentrations. Decreased concentrations of superoxide anion (O(2)(center dot-)), hydrogen peroxide (H(2)O(2)), nitrite (NO(2)(-)), peroxynitrite (ONOO(-)) and lipid peroxide (LPO) were found during estradiol therapy in erythrocytes. No changes were found in the activity of gluthatione-S-transferase (GST). The decrease of MAP values was positively correlated with the reduction of concentrations of O(2)(center dot-), H(2)O(2), NO(2)(-) and ONOO(-) in erythrocytes during estradiol therapy. The obtained results suggest that short-term intramuscular administration of estradiol shows antioxidative effects in erythrocytes and reduces blood pressure in preeclampsia. (C) 2009 Elsevier Inc. All rights reserved.
T2  - Reproductive Toxicology
T1  - The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia
IS  - 2
VL  - 29
EP  - 236
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1394
ER  - 

@article{
author = "Đorđević, Natasa Z and Babić, Goran M and Marković, Snezana D and Ognjanović, Branka I and Stajn, Andras S and Saičić, Zorica",
year = "2010",
abstract = "In the present study, we evaluated changes of both oxidative stress marker concentrations in erythrocytes and values of blood pressure, as well as their relation during short-term estradiol therapy in preeclampsia. Serum estradiol concentrations were also recorded. The results of this study showed significant decrease of mean arterial pressure (MAP) values during estradiol therapy, whereas there was no significant change in serum estradiol concentrations. Decreased concentrations of superoxide anion (O(2)(center dot-)), hydrogen peroxide (H(2)O(2)), nitrite (NO(2)(-)), peroxynitrite (ONOO(-)) and lipid peroxide (LPO) were found during estradiol therapy in erythrocytes. No changes were found in the activity of gluthatione-S-transferase (GST). The decrease of MAP values was positively correlated with the reduction of concentrations of O(2)(center dot-), H(2)O(2), NO(2)(-) and ONOO(-) in erythrocytes during estradiol therapy. The obtained results suggest that short-term intramuscular administration of estradiol shows antioxidative effects in erythrocytes and reduces blood pressure in preeclampsia. (C) 2009 Elsevier Inc. All rights reserved.",
journal = "Reproductive Toxicology",
title = "The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia",
number = "2",
volume = "29",
pages = "236",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1394"
}

Đorđević, N. Z., Babić, G. M., Marković, S. D., Ognjanović, B. I., Stajn, A. S.,& Saičić, Z.. (2010). The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia. in Reproductive Toxicology, 29(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1394

Đorđević NZ, Babić GM, Marković SD, Ognjanović BI, Stajn AS, Saičić Z. The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia. in Reproductive Toxicology. 2010;29(2):null-236.
https://hdl.handle.net/21.15107/rcub_ibiss_1394 .

Đorđević, Natasa Z, Babić, Goran M, Marković, Snezana D, Ognjanović, Branka I, Stajn, Andras S, Saičić, Zorica, "The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia" in Reproductive Toxicology, 29, no. 2 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1394 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Marković, Snezana D
AU  - Đorđević, Natasa Z
AU  - Trbojević, Ivana S
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1393
AB  - The aim of this study was to investigate the protective role of coenzyme Q(10) (CoQ(10), 20 mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4 mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ(10) and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ(10), and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQic, and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. (C) 2009 Elsevier Inc. All rights reserved.
T2  - Reproductive Toxicology
T1  - Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E
IS  - 2
VL  - 29
EP  - 197
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1393
ER  - 

@article{
author = "Ognjanović, Branka I and Marković, Snezana D and Đorđević, Natasa Z and Trbojević, Ivana S and Stajn, Andras S and Saičić, Zorica",
year = "2010",
abstract = "The aim of this study was to investigate the protective role of coenzyme Q(10) (CoQ(10), 20 mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4 mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ(10) and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ(10), and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQic, and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. (C) 2009 Elsevier Inc. All rights reserved.",
journal = "Reproductive Toxicology",
title = "Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E",
number = "2",
volume = "29",
pages = "197",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1393"
}

Ognjanović, B. I., Marković, S. D., Đorđević, N. Z., Trbojević, I. S., Stajn, A. S.,& Saičić, Z.. (2010). Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E. in Reproductive Toxicology, 29(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1393

Ognjanović BI, Marković SD, Đorđević NZ, Trbojević IS, Stajn AS, Saičić Z. Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E. in Reproductive Toxicology. 2010;29(2):null-197.
https://hdl.handle.net/21.15107/rcub_ibiss_1393 .

Ognjanović, Branka I, Marković, Snezana D, Đorđević, Natasa Z, Trbojević, Ivana S, Stajn, Andras S, Saičić, Zorica, "Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E" in Reproductive Toxicology, 29, no. 2 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1393 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Borković Mitić, Slavica
AU  - Radovanović, Tijana
AU  - Ognjanović, Branka I
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1558
AB  - The effects of locality and season on the activity of antioxidant defense enzymes (ADE), namely, total superoxide dismutase (Tot SOD), copper zinc containing superoxide dismutase (CuZn SOD), manganese containing superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) in the liver of red mullet (Mullus barbatus L.) from the Platamuni and Valdanos localities (Adriatic Sea) in winter and spring season were studied. All enzyme activities were expressed as specific (units/mg proteins) and total (units/g wet tissue) ones. Our results show increased specific and total activities of almost all investigated ADE in winter, with respect to the spring, both in Platamuni and Valdanos. The opposite effect was obtained for the specific and total GSH-Px activity at both localities. The presented results show that the activity of investigated ADE depends mainly on the analyzed season. Also, it was confirmed that biotransformation phase II enzyme GST is the most sensitive indicator of environmental status in the liver of red mullet. The results of Principal Component Analysis (PCA) based on correlations show similar trends in the positive and negative correlations between specific and total ADE in both seasons. At the same time, examination of seasonal patterns of ADE revealed clear differences between the investigated localities in winter and spring for specific and total activities. From the presented results, it can be concluded that seasonal variations of ADE should be incorporated into interpretation of further biomonitoring studies of red mullet.
PB  - Freising: Parlar Scientific Publications
T2  - Fresenius Environmental Bulletin
T1  - Antioxidant defense enzyme activities in the liver of red mullet (Mullus barbatus L.) from the Adriatic Sea: The effects of locality and season
IS  - 5
VL  - 17
SP  - 558
EP  - 563
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1558
ER  - 

@article{
author = "Pavlović, Slađan and Borković Mitić, Slavica and Radovanović, Tijana and Ognjanović, Branka I and Žikić, Radoslav V. and Stajn, Andras S and Saičić, Zorica",
year = "2008",
abstract = "The effects of locality and season on the activity of antioxidant defense enzymes (ADE), namely, total superoxide dismutase (Tot SOD), copper zinc containing superoxide dismutase (CuZn SOD), manganese containing superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) in the liver of red mullet (Mullus barbatus L.) from the Platamuni and Valdanos localities (Adriatic Sea) in winter and spring season were studied. All enzyme activities were expressed as specific (units/mg proteins) and total (units/g wet tissue) ones. Our results show increased specific and total activities of almost all investigated ADE in winter, with respect to the spring, both in Platamuni and Valdanos. The opposite effect was obtained for the specific and total GSH-Px activity at both localities. The presented results show that the activity of investigated ADE depends mainly on the analyzed season. Also, it was confirmed that biotransformation phase II enzyme GST is the most sensitive indicator of environmental status in the liver of red mullet. The results of Principal Component Analysis (PCA) based on correlations show similar trends in the positive and negative correlations between specific and total ADE in both seasons. At the same time, examination of seasonal patterns of ADE revealed clear differences between the investigated localities in winter and spring for specific and total activities. From the presented results, it can be concluded that seasonal variations of ADE should be incorporated into interpretation of further biomonitoring studies of red mullet.",
publisher = "Freising: Parlar Scientific Publications",
journal = "Fresenius Environmental Bulletin",
title = "Antioxidant defense enzyme activities in the liver of red mullet (Mullus barbatus L.) from the Adriatic Sea: The effects of locality and season",
number = "5",
volume = "17",
pages = "558-563",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1558"
}

Pavlović, S., Borković Mitić, S., Radovanović, T., Ognjanović, B. I., Žikić, R. V., Stajn, A. S.,& Saičić, Z.. (2008). Antioxidant defense enzyme activities in the liver of red mullet (Mullus barbatus L.) from the Adriatic Sea: The effects of locality and season. in Fresenius Environmental Bulletin
Freising: Parlar Scientific Publications., 17(5), 558-563.
https://hdl.handle.net/21.15107/rcub_ibiss_1558

Pavlović S, Borković Mitić S, Radovanović T, Ognjanović BI, Žikić RV, Stajn AS, Saičić Z. Antioxidant defense enzyme activities in the liver of red mullet (Mullus barbatus L.) from the Adriatic Sea: The effects of locality and season. in Fresenius Environmental Bulletin. 2008;17(5):558-563.
https://hdl.handle.net/21.15107/rcub_ibiss_1558 .

Pavlović, Slađan, Borković Mitić, Slavica, Radovanović, Tijana, Ognjanović, Branka I, Žikić, Radoslav V., Stajn, Andras S, Saičić, Zorica, "Antioxidant defense enzyme activities in the liver of red mullet (Mullus barbatus L.) from the Adriatic Sea: The effects of locality and season" in Fresenius Environmental Bulletin, 17, no. 5 (2008):558-563,
https://hdl.handle.net/21.15107/rcub_ibiss_1558 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Marković, Snezana D
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1562
UR  - http://www.biomed.cas.cz/physiolres/pdf/57/57_403.pdf
AB  - The effects of selenium ( Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl2 for 4 weeks) resulted in increased lipid peroxidation ( LP) in both organs (p < 0.005 and p < 0.01). Vitamin C (Vit C) was decreased in the liver ( p < 0.005), whereas vitamin E ( Vit E) was increased in the liver and kidneys ( p < 0.005 and p < 0.05) of Cd-exposed animals. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were decreased in both tissues ( p < 0.05 and p < 0.005), whereas catalase (CAT) activity was decreased only in liver ( p < 0.005). Glutathione S-transferase (GST) increased in both tissues ( p < 0.005 and p<0.01). Treatment with Se (0.5 mg Se/kg b.m./day as Na2SeO3 for 4 weeks) significantly increased liver and kidneys SOD and GSH-Px activities ( p < 0.05 to p < 0.005), as well as CAT and GST activities only in the liver ( p < 0.01). In animals exposed to Se, both the concentrations of Vit C ( p < 0.01) and Vit E (p < 0.005) were increased in both tissues. Co-treatment with Se resulted in reversal of oxidative stress with significant decline in analyzed tissues Cd burden. Our results show that Se may ameliorate Cd-induced oxidative stress by decreasing LP and altering antioxidant defense system in rat liver and kidneys and that Se demonstrates the protective effect from cadmium-induced oxidative damage.
T2  - Physiological Research
T1  - Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium
IS  - 3
VL  - 57
EP  - 411
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1562
ER  - 

@article{
author = "Ognjanović, Branka I and Marković, Snezana D and Pavlović, Slađan and Žikić, Radoslav V. and Stajn, Andras S and Saičić, Zorica",
year = "2008",
abstract = "The effects of selenium ( Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl2 for 4 weeks) resulted in increased lipid peroxidation ( LP) in both organs (p < 0.005 and p < 0.01). Vitamin C (Vit C) was decreased in the liver ( p < 0.005), whereas vitamin E ( Vit E) was increased in the liver and kidneys ( p < 0.005 and p < 0.05) of Cd-exposed animals. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were decreased in both tissues ( p < 0.05 and p < 0.005), whereas catalase (CAT) activity was decreased only in liver ( p < 0.005). Glutathione S-transferase (GST) increased in both tissues ( p < 0.005 and p<0.01). Treatment with Se (0.5 mg Se/kg b.m./day as Na2SeO3 for 4 weeks) significantly increased liver and kidneys SOD and GSH-Px activities ( p < 0.05 to p < 0.005), as well as CAT and GST activities only in the liver ( p < 0.01). In animals exposed to Se, both the concentrations of Vit C ( p < 0.01) and Vit E (p < 0.005) were increased in both tissues. Co-treatment with Se resulted in reversal of oxidative stress with significant decline in analyzed tissues Cd burden. Our results show that Se may ameliorate Cd-induced oxidative stress by decreasing LP and altering antioxidant defense system in rat liver and kidneys and that Se demonstrates the protective effect from cadmium-induced oxidative damage.",
journal = "Physiological Research",
title = "Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium",
number = "3",
volume = "57",
pages = "411",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1562"
}

Ognjanović, B. I., Marković, S. D., Pavlović, S., Žikić, R. V., Stajn, A. S.,& Saičić, Z.. (2008). Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium. in Physiological Research, 57(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1562

Ognjanović BI, Marković SD, Pavlović S, Žikić RV, Stajn AS, Saičić Z. Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium. in Physiological Research. 2008;57(3):null-411.
https://hdl.handle.net/21.15107/rcub_ibiss_1562 .

Ognjanović, Branka I, Marković, Snezana D, Pavlović, Slađan, Žikić, Radoslav V., Stajn, Andras S, Saičić, Zorica, "Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium" in Physiological Research, 57, no. 3 (2008),
https://hdl.handle.net/21.15107/rcub_ibiss_1562 .

TY  - JOUR
AU  - Marković, Snezana D
AU  - Vukajlović, Miroslava Đ
AU  - Ognjanović, Branka I
AU  - Stajn, Andras S
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Radojičić, Ratko M.
AU  - Jones, David R
AU  - Spasić, Mihajlo
PY  - 2007
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1602
AB  - After enzymic biotransformation, molsidomine (MO) acts via the metabolite 3-morpholmosydnonimine (SIN-1) through spontaneous liberation of nitric oxide (NO) and superoxide (O-2(.-)). The aim of this study was to compare the effects of MO and its active metabolite SIN-1 on the redox status of rat erythrocytes and reticulocytes. Rat erythrocyte as well as reticulocyte-rich red blood cell (RBC) suspensions were aerobically incubated (2h, 37 degrees C) without (control) or in the presence of different concentrations of MO or SIN-1. In rat erythrocytes, biotransformation of MO resulted in the production of NO and nitroxyl (NO-). Endogenous superoxide anion (O-2(.-)) participated in peroxynitrite generation. SIN-1 simultaneously liberated NO and O-2(.-), which formed peroxynitrite (at least in part), but the liberated NO predominantly reacted with haemoglobin, forming methaemoglobin in erythrocytes. In reticulocytes, MO and SIN-1 caused an increase in the levels of both nitrite and 3-nitrotyrosine (an indicator of peroxynitrite), whereas they decreased the level of O-2(.-). In reticulocytes, MO was metabolized into SIN-1 which led to the generation of NO, which reacted with O-2(.-) (endogenous or exogenous) forming reactive nitrogen species. In conclusion, there are two metabolic pathways for MO biotransformation: one causing NO and NO- generation predominantly in erythrocytes and the other, via SINA metabolism, in reticulocytes. The main difference between the action of MO and SIN-1 was that the latter caused oxidative damage in RBCs. Copyright (c) 2006 John Wiley & Sons, Ltd.
T2  - Cell Biochemistry and Function
T1  - A comparative study of the effects of molsidomine and 3-morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes
IS  - 3
VL  - 25
EP  - 258
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1602
ER  - 

@article{
author = "Marković, Snezana D and Vukajlović, Miroslava Đ and Ognjanović, Branka I and Stajn, Andras S and Žikić, Radoslav V. and Saičić, Zorica and Radojičić, Ratko M. and Jones, David R and Spasić, Mihajlo",
year = "2007",
abstract = "After enzymic biotransformation, molsidomine (MO) acts via the metabolite 3-morpholmosydnonimine (SIN-1) through spontaneous liberation of nitric oxide (NO) and superoxide (O-2(.-)). The aim of this study was to compare the effects of MO and its active metabolite SIN-1 on the redox status of rat erythrocytes and reticulocytes. Rat erythrocyte as well as reticulocyte-rich red blood cell (RBC) suspensions were aerobically incubated (2h, 37 degrees C) without (control) or in the presence of different concentrations of MO or SIN-1. In rat erythrocytes, biotransformation of MO resulted in the production of NO and nitroxyl (NO-). Endogenous superoxide anion (O-2(.-)) participated in peroxynitrite generation. SIN-1 simultaneously liberated NO and O-2(.-), which formed peroxynitrite (at least in part), but the liberated NO predominantly reacted with haemoglobin, forming methaemoglobin in erythrocytes. In reticulocytes, MO and SIN-1 caused an increase in the levels of both nitrite and 3-nitrotyrosine (an indicator of peroxynitrite), whereas they decreased the level of O-2(.-). In reticulocytes, MO was metabolized into SIN-1 which led to the generation of NO, which reacted with O-2(.-) (endogenous or exogenous) forming reactive nitrogen species. In conclusion, there are two metabolic pathways for MO biotransformation: one causing NO and NO- generation predominantly in erythrocytes and the other, via SINA metabolism, in reticulocytes. The main difference between the action of MO and SIN-1 was that the latter caused oxidative damage in RBCs. Copyright (c) 2006 John Wiley & Sons, Ltd.",
journal = "Cell Biochemistry and Function",
title = "A comparative study of the effects of molsidomine and 3-morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes",
number = "3",
volume = "25",
pages = "258",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1602"
}

Marković, S. D., Vukajlović, M. Đ., Ognjanović, B. I., Stajn, A. S., Žikić, R. V., Saičić, Z., Radojičić, R. M., Jones, D. R.,& Spasić, M.. (2007). A comparative study of the effects of molsidomine and 3-morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes. in Cell Biochemistry and Function, 25(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1602

Marković SD, Vukajlović MĐ, Ognjanović BI, Stajn AS, Žikić RV, Saičić Z, Radojičić RM, Jones DR, Spasić M. A comparative study of the effects of molsidomine and 3-morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes. in Cell Biochemistry and Function. 2007;25(3):null-258.
https://hdl.handle.net/21.15107/rcub_ibiss_1602 .

Marković, Snezana D, Vukajlović, Miroslava Đ, Ognjanović, Branka I, Stajn, Andras S, Žikić, Radoslav V., Saičić, Zorica, Radojičić, Ratko M., Jones, David R, Spasić, Mihajlo, "A comparative study of the effects of molsidomine and 3-morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes" in Cell Biochemistry and Function, 25, no. 3 (2007),
https://hdl.handle.net/21.15107/rcub_ibiss_1602 .

TY  - JOUR
AU  - Žikić, Radoslav V.
AU  - Ognjanović, Branka I
AU  - Marković, Snezana D
AU  - Pavlović, Slađan
AU  - Mihajlović, Ranđel P
AU  - Saičić, Zorica
AU  - Stajn, Andras S
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1650
AB  - Background and Purpose: Recent investigations in biomonitoring include the follow-up of biochemical and physiological parameters in order to estimate the condition of the environment. Oxidative stress parameters are significant biomarkers of ecological pollution of the sea. Materials and Methods: Specimens of red mullet (Mullus barbatus) were collected from the seawater at the localities of Platamuni and Valdanos (in the Adriatic Sea) both in winter and spring. The concentrations of lipid peroxides (LP), vitamin E (vit E) and vitamin C (vit C) were determined both in the liver and white muscle. Salinity, temperature, oxygen saturation, concentrations of nitrates and nitrites and detergents were determined in the seawater at the time of specimen collection. Results and Conclusions: The obtained results showed higher concentration of LP, vit E and vit C in the liver of red mullet when compared to white muscle. The concentrations of LP and vit C were higher, whereas the vit E concentration was lower in winter than in spring. In both the liver and white muscle (from Valdanos), higher concentration of LP and lower concentration of vit E were found when compared to those from Platamuni. Such changes in the oxidative stress parameters were in correlation with seasonal changes in temperature and the concentrations of nitrates, nitrites and detergents in the water. The intensity of oxidative stress in liver of red mullet was higher in comparison to muscles. It was also higher in winter compared to spring, and higher in Valdanos than in Platamuni. In conclusion, parameters of oxidative stress in tissues of red mullet are good markers for the biomonitoring of environment conditions.
T2  - Periodicum Biologorum
T1  - Lipid peroxidation and the concentration of antioxidant compounds (vitamin E and vitamin C) in the liver and white muscle of red mullet (Mullus barbatus L.) from the Adriatic Sea
IS  - 2
VL  - 108
EP  - 143
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1650
ER  - 

@article{
author = "Žikić, Radoslav V. and Ognjanović, Branka I and Marković, Snezana D and Pavlović, Slađan and Mihajlović, Ranđel P and Saičić, Zorica and Stajn, Andras S",
year = "2006",
abstract = "Background and Purpose: Recent investigations in biomonitoring include the follow-up of biochemical and physiological parameters in order to estimate the condition of the environment. Oxidative stress parameters are significant biomarkers of ecological pollution of the sea. Materials and Methods: Specimens of red mullet (Mullus barbatus) were collected from the seawater at the localities of Platamuni and Valdanos (in the Adriatic Sea) both in winter and spring. The concentrations of lipid peroxides (LP), vitamin E (vit E) and vitamin C (vit C) were determined both in the liver and white muscle. Salinity, temperature, oxygen saturation, concentrations of nitrates and nitrites and detergents were determined in the seawater at the time of specimen collection. Results and Conclusions: The obtained results showed higher concentration of LP, vit E and vit C in the liver of red mullet when compared to white muscle. The concentrations of LP and vit C were higher, whereas the vit E concentration was lower in winter than in spring. In both the liver and white muscle (from Valdanos), higher concentration of LP and lower concentration of vit E were found when compared to those from Platamuni. Such changes in the oxidative stress parameters were in correlation with seasonal changes in temperature and the concentrations of nitrates, nitrites and detergents in the water. The intensity of oxidative stress in liver of red mullet was higher in comparison to muscles. It was also higher in winter compared to spring, and higher in Valdanos than in Platamuni. In conclusion, parameters of oxidative stress in tissues of red mullet are good markers for the biomonitoring of environment conditions.",
journal = "Periodicum Biologorum",
title = "Lipid peroxidation and the concentration of antioxidant compounds (vitamin E and vitamin C) in the liver and white muscle of red mullet (Mullus barbatus L.) from the Adriatic Sea",
number = "2",
volume = "108",
pages = "143",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1650"
}

Žikić, R. V., Ognjanović, B. I., Marković, S. D., Pavlović, S., Mihajlović, R. P., Saičić, Z.,& Stajn, A. S.. (2006). Lipid peroxidation and the concentration of antioxidant compounds (vitamin E and vitamin C) in the liver and white muscle of red mullet (Mullus barbatus L.) from the Adriatic Sea. in Periodicum Biologorum, 108(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1650

Žikić RV, Ognjanović BI, Marković SD, Pavlović S, Mihajlović RP, Saičić Z, Stajn AS. Lipid peroxidation and the concentration of antioxidant compounds (vitamin E and vitamin C) in the liver and white muscle of red mullet (Mullus barbatus L.) from the Adriatic Sea. in Periodicum Biologorum. 2006;108(2):null-143.
https://hdl.handle.net/21.15107/rcub_ibiss_1650 .

Žikić, Radoslav V., Ognjanović, Branka I, Marković, Snezana D, Pavlović, Slađan, Mihajlović, Ranđel P, Saičić, Zorica, Stajn, Andras S, "Lipid peroxidation and the concentration of antioxidant compounds (vitamin E and vitamin C) in the liver and white muscle of red mullet (Mullus barbatus L.) from the Adriatic Sea" in Periodicum Biologorum, 108, no. 2 (2006),
https://hdl.handle.net/21.15107/rcub_ibiss_1650 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Marković, Snezana D
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1634
AB  - Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4 mg Cd/kg BW i.p.), CoQ(10) (20 mg CoQ(10)/kg BW i.m.) and Vit E (20 IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ10 and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ10 and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart. (c) 2006 Elsevier B.V. All rights reserved.
T2  - Environmental Toxicology and Pharmacology
T1  - Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart
IS  - 2
VL  - 22
EP  - 224
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1634
ER  - 

@article{
author = "Ognjanović, Branka I and Marković, Snezana D and Pavlović, Slađan and Žikić, Radoslav V. and Stajn, Andras S and Saičić, Zorica",
year = "2006",
abstract = "Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4 mg Cd/kg BW i.p.), CoQ(10) (20 mg CoQ(10)/kg BW i.m.) and Vit E (20 IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ10 and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ10 and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart. (c) 2006 Elsevier B.V. All rights reserved.",
journal = "Environmental Toxicology and Pharmacology",
title = "Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart",
number = "2",
volume = "22",
pages = "224",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1634"
}

Ognjanović, B. I., Marković, S. D., Pavlović, S., Žikić, R. V., Stajn, A. S.,& Saičić, Z.. (2006). Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart. in Environmental Toxicology and Pharmacology, 22(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1634

Ognjanović BI, Marković SD, Pavlović S, Žikić RV, Stajn AS, Saičić Z. Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart. in Environmental Toxicology and Pharmacology. 2006;22(2):null-224.
https://hdl.handle.net/21.15107/rcub_ibiss_1634 .

Ognjanović, Branka I, Marković, Snezana D, Pavlović, Slađan, Žikić, Radoslav V., Stajn, Andras S, Saičić, Zorica, "Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart" in Environmental Toxicology and Pharmacology, 22, no. 2 (2006),
https://hdl.handle.net/21.15107/rcub_ibiss_1634 .

TY  - JOUR
AU  - Maletić, Snezana D
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Ognjanović, Branka I
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Spasić, Mihajlo
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1757
AB  - The effects of the sodium nitroprusside (SNP), a nitric oxide (NO) donor clinically used in the treatment of hypertensive emergencies on the energy production of rat reticulocytes were investigated. Rat reticulocyte-rich red blood cell suspensions were aerobically incubated without (control) or in the presence of different concentrations of SNP (0.1, 0.25, 0.5, 1.0 mM). SNP decreased total and coupled, but increased uncoupled oxygen consumption. This was accompanied by the stimulation of glycolysis, as measured by increased glucose consumption and lactate accumulation. Levels of all glycolytic intermediates indicate stimulation of hexokinase-phosphofructo kinase (HK-PFK), glyceraldehyde 3-phosphate dehydrogenase (GAPD) and pyruvate kinase (PK) activities in the presence of SNP. Due to the decrease of coupled oxygen consumption in the presence of SNP, ATP production via oxidative phosphorylation was significantly diminished. Simultaneous increase of glycolytic ATP production was not enough to provide constant ATP production. In addition, SNP significantly decreased ATP level, which was accompanied with increased ADP and AMP levels. However, the level of total adenine nucleotides was significantly lower, which was the consequence of increased catabolism of adenine nucleotides (increased hypoxanthine level). ATP/ADP ratio and adenylate energy charge level were significantly decreased. In conclusion, SNP induced inhibition of oxidative phosphorylation, stimulation of glycolysis, but depletion of total energy production in rat reticulocytes. These alterations were accompanied with instability of energy status.
T2  - Physiological Research
T1  - Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes
IS  - 4
VL  - 53
EP  - 447
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1757
ER  - 

@article{
author = "Maletić, Snezana D and Dragićević-Đoković, Ljiljana M. and Ognjanović, Branka I and Žikić, Radoslav V. and Stajn, Andras S and Spasić, Mihajlo",
year = "2004",
abstract = "The effects of the sodium nitroprusside (SNP), a nitric oxide (NO) donor clinically used in the treatment of hypertensive emergencies on the energy production of rat reticulocytes were investigated. Rat reticulocyte-rich red blood cell suspensions were aerobically incubated without (control) or in the presence of different concentrations of SNP (0.1, 0.25, 0.5, 1.0 mM). SNP decreased total and coupled, but increased uncoupled oxygen consumption. This was accompanied by the stimulation of glycolysis, as measured by increased glucose consumption and lactate accumulation. Levels of all glycolytic intermediates indicate stimulation of hexokinase-phosphofructo kinase (HK-PFK), glyceraldehyde 3-phosphate dehydrogenase (GAPD) and pyruvate kinase (PK) activities in the presence of SNP. Due to the decrease of coupled oxygen consumption in the presence of SNP, ATP production via oxidative phosphorylation was significantly diminished. Simultaneous increase of glycolytic ATP production was not enough to provide constant ATP production. In addition, SNP significantly decreased ATP level, which was accompanied with increased ADP and AMP levels. However, the level of total adenine nucleotides was significantly lower, which was the consequence of increased catabolism of adenine nucleotides (increased hypoxanthine level). ATP/ADP ratio and adenylate energy charge level were significantly decreased. In conclusion, SNP induced inhibition of oxidative phosphorylation, stimulation of glycolysis, but depletion of total energy production in rat reticulocytes. These alterations were accompanied with instability of energy status.",
journal = "Physiological Research",
title = "Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes",
number = "4",
volume = "53",
pages = "447",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1757"
}

Maletić, S. D., Dragićević-Đoković, L. M., Ognjanović, B. I., Žikić, R. V., Stajn, A. S.,& Spasić, M.. (2004). Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes. in Physiological Research, 53(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1757

Maletić SD, Dragićević-Đoković LM, Ognjanović BI, Žikić RV, Stajn AS, Spasić M. Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes. in Physiological Research. 2004;53(4):null-447.
https://hdl.handle.net/21.15107/rcub_ibiss_1757 .

Maletić, Snezana D, Dragićević-Đoković, Ljiljana M., Ognjanović, Branka I, Žikić, Radoslav V., Stajn, Andras S, Spasić, Mihajlo, "Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes" in Physiological Research, 53, no. 4 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1757 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Pavlović, Slađan
AU  - Maletić, Snezana D
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Radojičić, Ratko M.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1783
AB  - The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E+Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system.
T2  - Physiological Research
T1  - Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium
IS  - 5
VL  - 52
EP  - 570
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1783
ER  - 

@article{
author = "Ognjanović, Branka I and Pavlović, Slađan and Maletić, Snezana D and Žikić, Radoslav V. and Stajn, Andras S and Radojičić, Ratko M. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2003",
abstract = "The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E+Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system.",
journal = "Physiological Research",
title = "Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium",
number = "5",
volume = "52",
pages = "570",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1783"
}

Ognjanović, B. I., Pavlović, S., Maletić, S. D., Žikić, R. V., Stajn, A. S., Radojičić, R. M., Saičić, Z.,& Petrović, V. M.. (2003). Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. in Physiological Research, 52(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1783

Ognjanović BI, Pavlović S, Maletić SD, Žikić RV, Stajn AS, Radojičić RM, Saičić Z, Petrović VM. Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. in Physiological Research. 2003;52(5):null-570.
https://hdl.handle.net/21.15107/rcub_ibiss_1783 .

Ognjanović, Branka I, Pavlović, Slađan, Maletić, Snezana D, Žikić, Radoslav V., Stajn, Andras S, Radojičić, Ratko M., Saičić, Zorica, Petrović, Vojislav M., "Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium" in Physiological Research, 52, no. 5 (2003),
https://hdl.handle.net/21.15107/rcub_ibiss_1783 .

TY  - CONF
AU  - Ognjanović, Branka I
AU  - Pavlović, Slađan
AU  - Maletić, Snezana D
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1805
C3  - Free Radical Biology and Medicine
T1  - The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium
IS  - null
VL  - 33
EP  - S104
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1805
ER  - 

@conference{
author = "Ognjanović, Branka I and Pavlović, Slađan and Maletić, Snezana D and Žikić, Radoslav V. and Stajn, Andras S and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
journal = "Free Radical Biology and Medicine",
title = "The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium",
number = "null",
volume = "33",
pages = "S104",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1805"
}

Ognjanović, B. I., Pavlović, S., Maletić, S. D., Žikić, R. V., Stajn, A. S., Saičić, Z.,& Petrović, V. M.. (2002). The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Free Radical Biology and Medicine, 33(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1805

Ognjanović BI, Pavlović S, Maletić SD, Žikić RV, Stajn AS, Saičić Z, Petrović VM. The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Free Radical Biology and Medicine. 2002;33(null):null-S104.
https://hdl.handle.net/21.15107/rcub_ibiss_1805 .

Ognjanović, Branka I, Pavlović, Slađan, Maletić, Snezana D, Žikić, Radoslav V., Stajn, Andras S, Saičić, Zorica, Petrović, Vojislav M., "The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium" in Free Radical Biology and Medicine, 33, no. null (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1805 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Maletić, Snežana D.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Radojičić, Ratko M.
AU  - Saičić, Zorica
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/23
AB  - The present study investigated the possible protective role of olive oil on antioxidative defense components in liver of cadmium (Cd) intoxicated animals. Male, Wistar albino 3 months old rats were injected with a single dose of: 1) CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24h), 2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and 3) olive oil + Cd (in above mentioned amounts). Treatment with Cd increased lipid peroxidation (LP) in blood and activities of alanine and aspartate transaminase (ALT and AST) in plasma. Concentrations of non enzymatic components of antioxidative defense system (AOS): vitamin C (Vit C) and vitamin E (Vit E) were significantly decreased in liver tissue of Cd treated rats. Pretreatment with olive oil reversed Cd induced alterations in LP content and transaminases activities, as well as on endogenous antioxidive defense components.
AB  - U ovom radu ispitivana je moguća zaštitna uloga maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova intoksiciranim kadmijumom (Cd). Mužjaci pacova Wistar albino, starosti tri meseca akutno su tretirani sa: 1) CdCl (0.4 mg Cd/kg t.m., i.p., 24h pre žrtvovanja), 2) maslinovim uljem (0.4 ml maslinovog ulja/kg t.m., i.m., 48h pre žrtvovanja) i 3) maslinovim uljem + Cd (u navedenim količinama). Posle tretmana kadmijumom značajno se povećava koncentracija lipidnih peroksida (LP) u krvi, kao i aktivnost alanin i aspartat transaminaza (ALT i AST) u plazmi. Koncentracije neenzimskih komponenti antioksidacionog zaštitnog sistema (AOS): vitamin C (Vit C) i vitamin E (Vit E) su značajno smanjene u jetri kod pacova tretiranih kadmijumom. Eksperimenti sa pacovima koji su u pred tretmanu dobijali maslinovo ulje pokazuju da maslinovo ulje sprečava ili ublažava kadmijumom izazvane promene u koncentraciji LP, aktivnosti, kao i koncentraciji endogenih antioksidacionih zaštitnih komponenti.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom
T1  - Effect of olive oil on antioxidative defense components in liver of cadmium intoxicated rats
IS  - 3
VL  - 38
SP  - 101
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_23
ER  - 

@article{
author = "Ognjanović, Branka I. and Maletić, Snežana D. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Radojičić, Ratko M. and Saičić, Zorica",
year = "2002",
abstract = "The present study investigated the possible protective role of olive oil on antioxidative defense components in liver of cadmium (Cd) intoxicated animals. Male, Wistar albino 3 months old rats were injected with a single dose of: 1) CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24h), 2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and 3) olive oil + Cd (in above mentioned amounts). Treatment with Cd increased lipid peroxidation (LP) in blood and activities of alanine and aspartate transaminase (ALT and AST) in plasma. Concentrations of non enzymatic components of antioxidative defense system (AOS): vitamin C (Vit C) and vitamin E (Vit E) were significantly decreased in liver tissue of Cd treated rats. Pretreatment with olive oil reversed Cd induced alterations in LP content and transaminases activities, as well as on endogenous antioxidive defense components., U ovom radu ispitivana je moguća zaštitna uloga maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova intoksiciranim kadmijumom (Cd). Mužjaci pacova Wistar albino, starosti tri meseca akutno su tretirani sa: 1) CdCl (0.4 mg Cd/kg t.m., i.p., 24h pre žrtvovanja), 2) maslinovim uljem (0.4 ml maslinovog ulja/kg t.m., i.m., 48h pre žrtvovanja) i 3) maslinovim uljem + Cd (u navedenim količinama). Posle tretmana kadmijumom značajno se povećava koncentracija lipidnih peroksida (LP) u krvi, kao i aktivnost alanin i aspartat transaminaza (ALT i AST) u plazmi. Koncentracije neenzimskih komponenti antioksidacionog zaštitnog sistema (AOS): vitamin C (Vit C) i vitamin E (Vit E) su značajno smanjene u jetri kod pacova tretiranih kadmijumom. Eksperimenti sa pacovima koji su u pred tretmanu dobijali maslinovo ulje pokazuju da maslinovo ulje sprečava ili ublažava kadmijumom izazvane promene u koncentraciji LP, aktivnosti, kao i koncentraciji endogenih antioksidacionih zaštitnih komponenti.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom, Effect of olive oil on antioxidative defense components in liver of cadmium intoxicated rats",
number = "3",
volume = "38",
pages = "101-110",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_23"
}

Ognjanović, B. I., Maletić, S. D., Pavlović, S., Žikić, R. V., Štajn, A. Š., Radojičić, R. M.,& Saičić, Z.. (2002). Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38(3), 101-110.
https://hdl.handle.net/21.15107/rcub_ibiss_23

Ognjanović BI, Maletić SD, Pavlović S, Žikić RV, Štajn AŠ, Radojičić RM, Saičić Z. Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2002;38(3):101-110.
https://hdl.handle.net/21.15107/rcub_ibiss_23 .

Ognjanović, Branka I., Maletić, Snežana D., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Radojičić, Ratko M., Saičić, Zorica, "Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38, no. 3 (2002):101-110,
https://hdl.handle.net/21.15107/rcub_ibiss_23 .

TY  - JOUR
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I
AU  - Saičić, Zorica
PY  - 2001
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1826
AB  - Four groups of goldfish were exposed to cadmium in a concentration of 20 mg Cd/l water under aquarium conditions. The duration of exposure was 1, 4, 7 and 15 days. It was shown that the activity of superoxide dismutase (SOD) in the red blood cells (RBC) significantly decreased after the first day of cadmium exposure. However, the SOD activity increased after 7 and 15 days of cadmium treatment. Elevated activity of catalase (CAT) was found in erythrocytes of cadmium-treated fishes after 15 days, whereas plasma GOT levels was increased after 7 and 15 days and GPT levels after 1, 4, 7 and 15 days of cadmium treatment. This was accompanied by a significant decrease of blood hemoglobin concentrations (after 15 days) and hematocrit values (after 7 and 15 days). However, the concentration of blood glucose significantly increased after 1, 4, 7 and 15 days of cadmium exposure. These results indicate that cadmium causes oxidative stress and tissue damage in the exposed fishes.
T2  - Physiological Research
T1  - Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch.) exposed to cadmium
IS  - 1
VL  - 50
EP  - 111
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1826
ER  - 

@article{
author = "Žikić, Radoslav V. and Stajn, Andras S and Pavlović, Slađan and Ognjanović, Branka I and Saičić, Zorica",
year = "2001",
abstract = "Four groups of goldfish were exposed to cadmium in a concentration of 20 mg Cd/l water under aquarium conditions. The duration of exposure was 1, 4, 7 and 15 days. It was shown that the activity of superoxide dismutase (SOD) in the red blood cells (RBC) significantly decreased after the first day of cadmium exposure. However, the SOD activity increased after 7 and 15 days of cadmium treatment. Elevated activity of catalase (CAT) was found in erythrocytes of cadmium-treated fishes after 15 days, whereas plasma GOT levels was increased after 7 and 15 days and GPT levels after 1, 4, 7 and 15 days of cadmium treatment. This was accompanied by a significant decrease of blood hemoglobin concentrations (after 15 days) and hematocrit values (after 7 and 15 days). However, the concentration of blood glucose significantly increased after 1, 4, 7 and 15 days of cadmium exposure. These results indicate that cadmium causes oxidative stress and tissue damage in the exposed fishes.",
journal = "Physiological Research",
title = "Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch.) exposed to cadmium",
number = "1",
volume = "50",
pages = "111",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1826"
}

Žikić, R. V., Stajn, A. S., Pavlović, S., Ognjanović, B. I.,& Saičić, Z.. (2001). Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch.) exposed to cadmium. in Physiological Research, 50(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1826

Žikić RV, Stajn AS, Pavlović S, Ognjanović BI, Saičić Z. Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch.) exposed to cadmium. in Physiological Research. 2001;50(1):null-111.
https://hdl.handle.net/21.15107/rcub_ibiss_1826 .

Žikić, Radoslav V., Stajn, Andras S, Pavlović, Slađan, Ognjanović, Branka I, Saičić, Zorica, "Activities of superoxide dismutase and catalase in erythrocytes and plasma transaminases of goldfish (Carassius auratus gibelio Bloch.) exposed to cadmium" in Physiological Research, 50, no. 1 (2001),
https://hdl.handle.net/21.15107/rcub_ibiss_1826 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I
AU  - Stajn, Andras S
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1812
AB  - The effect of cadmium, coenzyme Q(10) and cadmium+coenzyme Q10 on the activities of superoxide dismutases (total, manganese containing and copper-zinc containing), catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and concentrations of ascorbic acid, vitamin E, coenzyme Q, total protein contents and cadmium concentration in skeletal muscle of male Wistar albino rats were studied in comparison to the control animals. Increased activities of total and copper-zinc containing superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase, and decreased activity of manganese containing superoxide dismutase in cadmium treated rats were observed. In coenzyme Q10 treated animals the activities of total and manganese containing superoxide dismutase were decreased, while glutathione peroxidase and glutathione reductase activities were increased. In rats treated with cadmium+coenryme Q10 the activity of manganese containing superoxide dismutase was decreased, whereas the activities of catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase were increased, Concentrations of ascorbic acid and vitamin E were increased in all examined groups of animals, while coenzyme Q concentration was increased in coenzyme Q10 and cadmium+coenzyme Q10 treated rats. Cadmium decreased, while coenzyme Q10 increased the total protein contents. Accumulation of cadmium in skeletal muscle of rats treated with cadmium and cadmium+coenzyme Q10 was also observed.
T2  - Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry
T1  - Antioxidant defense system in skeletal muscle of rats treated with cadmium a possible protective role of coenzyme Q(10)
IS  - 4
VL  - 20
EP  - 235
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1812
ER  - 

@article{
author = "Pavlović, Slađan and Ognjanović, Branka I and Stajn, Andras S and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The effect of cadmium, coenzyme Q(10) and cadmium+coenzyme Q10 on the activities of superoxide dismutases (total, manganese containing and copper-zinc containing), catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and concentrations of ascorbic acid, vitamin E, coenzyme Q, total protein contents and cadmium concentration in skeletal muscle of male Wistar albino rats were studied in comparison to the control animals. Increased activities of total and copper-zinc containing superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase, and decreased activity of manganese containing superoxide dismutase in cadmium treated rats were observed. In coenzyme Q10 treated animals the activities of total and manganese containing superoxide dismutase were decreased, while glutathione peroxidase and glutathione reductase activities were increased. In rats treated with cadmium+coenryme Q10 the activity of manganese containing superoxide dismutase was decreased, whereas the activities of catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase were increased, Concentrations of ascorbic acid and vitamin E were increased in all examined groups of animals, while coenzyme Q concentration was increased in coenzyme Q10 and cadmium+coenzyme Q10 treated rats. Cadmium decreased, while coenzyme Q10 increased the total protein contents. Accumulation of cadmium in skeletal muscle of rats treated with cadmium and cadmium+coenzyme Q10 was also observed.",
journal = "Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry",
title = "Antioxidant defense system in skeletal muscle of rats treated with cadmium a possible protective role of coenzyme Q(10)",
number = "4",
volume = "20",
pages = "235",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1812"
}

Pavlović, S., Ognjanović, B. I., Stajn, A. S., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). Antioxidant defense system in skeletal muscle of rats treated with cadmium a possible protective role of coenzyme Q(10). in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 20(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1812

Pavlović S, Ognjanović BI, Stajn AS, Žikić RV, Saičić Z, Petrović VM. Antioxidant defense system in skeletal muscle of rats treated with cadmium a possible protective role of coenzyme Q(10). in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry. 2001;20(4):null-235.
https://hdl.handle.net/21.15107/rcub_ibiss_1812 .

Pavlović, Slađan, Ognjanović, Branka I, Stajn, Andras S, Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "Antioxidant defense system in skeletal muscle of rats treated with cadmium a possible protective role of coenzyme Q(10)" in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 20, no. 4 (2001),
https://hdl.handle.net/21.15107/rcub_ibiss_1812 .

TY  - JOUR
AU  - Stajn, A
AU  - Zikić, RV
AU  - Ognjanović, Branka I
AU  - Saičić, Zorica
AU  - Pavlović, Slađan
AU  - Kostić, MM
AU  - Petrović, Vojislav M.
PY  - 1997
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1873
AB  - To examine effects of exogenous Cd on the kidney antioxidant defense system (AOS) and the possible protective role of Se against Cd toxicity, male Wistar albino rats (2 months old) were exposed during 30 days to oral intake of 200 ppm Cd (as CdCl2), 0.1 ppm Se (as Na-selenite) or to the same dosages of Cd + Se, simultaneously. Marked accumulation of Cd (23.44 +/- 0.69 mu g/g w.m.) and marked alterations of AOS, resulting in kidney injury (renal pseudohypertrophy), were found in Cd-treated rats. Activities of total superoxide dismutase (SOD, EC 1.15.1.1), manganese-containing superoxide dismutase (MnSOD) and selenium-dependent glutathione peroxidase (Se GSH-Px, EG 1.11.1.9) were significantly reduced, whereas that of glutathione-S-transferase (CST, EC 2.5.1.18) and vitamin E (vit E) concentration were significantly increased in the kidneys of Cd-treated rats. Kidney catalase (CAT, EC 1.11.1.6) activity, ascorbic acid (AsA) and red blood cell glutathione one (GSH, GSSG) levels were not markedly influenced by Cd uptake. In kidneys of Se treated rats, the activities of total SOD, copper-zinc-containing superoxide dismutase (CuZnSOD) and GST were significantly increased. Activities of kidney CAT and Se GSH-Px were largely unchanged, whereas significant increases of the kidney AsA and vit E concentrations occurred. In Cd + Se-cotreated rats, the kidney activities of MnSOD, CAT and Se GSH-Px, as well as vit E concentration, were the same as in controls, whereas CuZnSOD and GST activities and concentration of AsA exceeded normal values. These data indicate that Se only partially improves the AOS that is insufficient to prevent Cd-induced nephrotoxicity. (C) 1997 Elsevier Science Inc.
T2  - Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology
T1  - Effect of cadmium and selenium on the antioxidant defense system in rat kidneys
IS  - 2
VL  - 117
EP  - 172
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1873
ER  - 

@article{
author = "Stajn, A and Zikić, RV and Ognjanović, Branka I and Saičić, Zorica and Pavlović, Slađan and Kostić, MM and Petrović, Vojislav M.",
year = "1997",
abstract = "To examine effects of exogenous Cd on the kidney antioxidant defense system (AOS) and the possible protective role of Se against Cd toxicity, male Wistar albino rats (2 months old) were exposed during 30 days to oral intake of 200 ppm Cd (as CdCl2), 0.1 ppm Se (as Na-selenite) or to the same dosages of Cd + Se, simultaneously. Marked accumulation of Cd (23.44 +/- 0.69 mu g/g w.m.) and marked alterations of AOS, resulting in kidney injury (renal pseudohypertrophy), were found in Cd-treated rats. Activities of total superoxide dismutase (SOD, EC 1.15.1.1), manganese-containing superoxide dismutase (MnSOD) and selenium-dependent glutathione peroxidase (Se GSH-Px, EG 1.11.1.9) were significantly reduced, whereas that of glutathione-S-transferase (CST, EC 2.5.1.18) and vitamin E (vit E) concentration were significantly increased in the kidneys of Cd-treated rats. Kidney catalase (CAT, EC 1.11.1.6) activity, ascorbic acid (AsA) and red blood cell glutathione one (GSH, GSSG) levels were not markedly influenced by Cd uptake. In kidneys of Se treated rats, the activities of total SOD, copper-zinc-containing superoxide dismutase (CuZnSOD) and GST were significantly increased. Activities of kidney CAT and Se GSH-Px were largely unchanged, whereas significant increases of the kidney AsA and vit E concentrations occurred. In Cd + Se-cotreated rats, the kidney activities of MnSOD, CAT and Se GSH-Px, as well as vit E concentration, were the same as in controls, whereas CuZnSOD and GST activities and concentration of AsA exceeded normal values. These data indicate that Se only partially improves the AOS that is insufficient to prevent Cd-induced nephrotoxicity. (C) 1997 Elsevier Science Inc.",
journal = "Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology",
title = "Effect of cadmium and selenium on the antioxidant defense system in rat kidneys",
number = "2",
volume = "117",
pages = "172",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1873"
}

Stajn, A., Zikić, R., Ognjanović, B. I., Saičić, Z., Pavlović, S., Kostić, M.,& Petrović, V. M.. (1997). Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. in Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 117(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1873

Stajn A, Zikić R, Ognjanović BI, Saičić Z, Pavlović S, Kostić M, Petrović VM. Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. in Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology. 1997;117(2):null-172.
https://hdl.handle.net/21.15107/rcub_ibiss_1873 .

Stajn, A, Zikić, RV, Ognjanović, Branka I, Saičić, Zorica, Pavlović, Slađan, Kostić, MM, Petrović, Vojislav M., "Effect of cadmium and selenium on the antioxidant defense system in rat kidneys" in Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 117, no. 2 (1997),
https://hdl.handle.net/21.15107/rcub_ibiss_1873 .