TY  - CONF
AU  - Perić Mataruga, Vesna
AU  - Lazarević, Jelica
AU  - Blagojević, Duško
AU  - Pavlović, Slađan
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5956
AB  - Lymantria dispar L. a polyphagous herbivore is the most dangerous insect pest of forest and fruit trees. Its host range is estimated at more than 500 plant species from 73 families (Lance, I 983, Liebhold et al., 1995). 111e locust tree Robinia pseudoacaccia is a plant that the gypsy moth avoids as a food (Barbosa and Krischik, 1987). Locust tree leaves contain large quantities of alkaloids and flavonoids (Bagrbosa & Krischik 1987). Some of them may have toxic and prooxidant effects (Hodnick et al., 1986). Gypsy moth populations in locust tree forest are rare (Jankovic 1958). The ingestion of oxidizable flavonoids can exacerbate oxidative stress in herbivorous insects (Ahmad, 1992; Felton and Summers, 1995; Pardini, 1995). The flavonoid quercetin used in this experiment was chosen as test prooxidant plant allelochemical. Upon insect ingestion quercetin is metabollicaly activated by one-electron oxidation to a free radical (o­ semiquinone) which in turn reacts with 02 (oxygen) to generate 0{
(superoxide anion radical) and consequently H202 (hydrogen peroxide) and
OH (hydroxyl radical) resulting in numerous destructive reactions in insect cell (Hodnick et al.,1986; Hodnick et al.,1989).
PB  - Debrecen: Debrecen University
C3  - From ideas to implementation challenge and practice of plant protection in the beginning of the 21 century: 3rd International Plant Protection Symposium (3rd IPPS) at Debrecen University: 8th Trans-Tisza Plant Protection Forum; 2003 Oct 15-16; Debrecen, Hungary
T1  - Response of the antioxidative defence to flavonoid quercetin in two populations of Lymantria dispar L.
SP  - 252
EP  - 260
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5956
ER  - 

@conference{
author = "Perić Mataruga, Vesna and Lazarević, Jelica and Blagojević, Duško and Pavlović, Slađan",
year = "2003",
abstract = "Lymantria dispar L. a polyphagous herbivore is the most dangerous insect pest of forest and fruit trees. Its host range is estimated at more than 500 plant species from 73 families (Lance, I 983, Liebhold et al., 1995). 111e locust tree Robinia pseudoacaccia is a plant that the gypsy moth avoids as a food (Barbosa and Krischik, 1987). Locust tree leaves contain large quantities of alkaloids and flavonoids (Bagrbosa & Krischik 1987). Some of them may have toxic and prooxidant effects (Hodnick et al., 1986). Gypsy moth populations in locust tree forest are rare (Jankovic 1958). The ingestion of oxidizable flavonoids can exacerbate oxidative stress in herbivorous insects (Ahmad, 1992; Felton and Summers, 1995; Pardini, 1995). The flavonoid quercetin used in this experiment was chosen as test prooxidant plant allelochemical. Upon insect ingestion quercetin is metabollicaly activated by one-electron oxidation to a free radical (o­ semiquinone) which in turn reacts with 02 (oxygen) to generate 0{
(superoxide anion radical) and consequently H202 (hydrogen peroxide) and
OH (hydroxyl radical) resulting in numerous destructive reactions in insect cell (Hodnick et al.,1986; Hodnick et al.,1989).",
publisher = "Debrecen: Debrecen University",
journal = "From ideas to implementation challenge and practice of plant protection in the beginning of the 21 century: 3rd International Plant Protection Symposium (3rd IPPS) at Debrecen University: 8th Trans-Tisza Plant Protection Forum; 2003 Oct 15-16; Debrecen, Hungary",
title = "Response of the antioxidative defence to flavonoid quercetin in two populations of Lymantria dispar L.",
pages = "252-260",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5956"
}

Perić Mataruga, V., Lazarević, J., Blagojević, D.,& Pavlović, S.. (2003). Response of the antioxidative defence to flavonoid quercetin in two populations of Lymantria dispar L.. in From ideas to implementation challenge and practice of plant protection in the beginning of the 21 century: 3rd International Plant Protection Symposium (3rd IPPS) at Debrecen University: 8th Trans-Tisza Plant Protection Forum; 2003 Oct 15-16; Debrecen, Hungary
Debrecen: Debrecen University., 252-260.
https://hdl.handle.net/21.15107/rcub_ibiss_5956

Perić Mataruga V, Lazarević J, Blagojević D, Pavlović S. Response of the antioxidative defence to flavonoid quercetin in two populations of Lymantria dispar L.. in From ideas to implementation challenge and practice of plant protection in the beginning of the 21 century: 3rd International Plant Protection Symposium (3rd IPPS) at Debrecen University: 8th Trans-Tisza Plant Protection Forum; 2003 Oct 15-16; Debrecen, Hungary. 2003;:252-260.
https://hdl.handle.net/21.15107/rcub_ibiss_5956 .

Perić Mataruga, Vesna, Lazarević, Jelica, Blagojević, Duško, Pavlović, Slađan, "Response of the antioxidative defence to flavonoid quercetin in two populations of Lymantria dispar L." in From ideas to implementation challenge and practice of plant protection in the beginning of the 21 century: 3rd International Plant Protection Symposium (3rd IPPS) at Debrecen University: 8th Trans-Tisza Plant Protection Forum; 2003 Oct 15-16; Debrecen, Hungary (2003):252-260,
https://hdl.handle.net/21.15107/rcub_ibiss_5956 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6020
AB  - In our study we investigated the effects of exogenous cadmium (Cd,  17 mg /day /kg  b.m.  in drinking  water), coenzyme  Q10 (CoQ 10, 16 mg/kg/dose CoQ10 dissolved in  olive  oil,  i.m.,  every  fifth  day) and Cd+CoQ10 (i n above mentioned amou nt s)  on  antioxidant  de­ fense enzyme activities (Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GST and  GR)  in  interscapular  hrown  adipose  tis sue (IBAT) of  male two  months  old  Wistar albin o rats during  30 days.
Cd induces significantly increased Mn SOD activity, while concomitant treatment of animals with  Cd+CoQ10  reversed  this change.   The  activity   of  CuZn   SOD   was  significantly  decreased
both in Cd and Cd+CoQ10 treated animals. CAT activity was sig­ nificantly increased in rats treated with Cd, whereas Cd+CoQ 10 normalized the activity of this enzyme. The activity of GSH-Px was significantly increased in all investigated groups of animals. Cd in­ duces an increased activity of GST,  but  by concomitant  treatment of rats with Cd+CoQ10 the GST activity was retained . The activity of GR was significantly increased in Cd treated animals, while in rats treated with Cd+CoQ10  was signi fican tl y decre_ased.
It can be concluded that Cd  induces  oxidativ  e stress  and  a l ter the activities of some antioxidant  defense  enzymes  in  IBAT of  rats. It is also shown that CoQ 10 can  normal ized  Mn  SOD,  CAT  a nd GST  activities  after  Cd-induced  changes .
PB  - Cadiz: Univerzidad de Cadiz
C3  - Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain
T1  - Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10
SP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6020
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2003",
abstract = "In our study we investigated the effects of exogenous cadmium (Cd,  17 mg /day /kg  b.m.  in drinking  water), coenzyme  Q10 (CoQ 10, 16 mg/kg/dose CoQ10 dissolved in  olive  oil,  i.m.,  every  fifth  day) and Cd+CoQ10 (i n above mentioned amou nt s)  on  antioxidant  de­ fense enzyme activities (Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GST and  GR)  in  interscapular  hrown  adipose  tis sue (IBAT) of  male two  months  old  Wistar albin o rats during  30 days.
Cd induces significantly increased Mn SOD activity, while concomitant treatment of animals with  Cd+CoQ10  reversed  this change.   The  activity   of  CuZn   SOD   was  significantly  decreased
both in Cd and Cd+CoQ10 treated animals. CAT activity was sig­ nificantly increased in rats treated with Cd, whereas Cd+CoQ 10 normalized the activity of this enzyme. The activity of GSH-Px was significantly increased in all investigated groups of animals. Cd in­ duces an increased activity of GST,  but  by concomitant  treatment of rats with Cd+CoQ10 the GST activity was retained . The activity of GR was significantly increased in Cd treated animals, while in rats treated with Cd+CoQ10  was signi fican tl y decre_ased.
It can be concluded that Cd  induces  oxidativ  e stress  and  a l ter the activities of some antioxidant  defense  enzymes  in  IBAT of  rats. It is also shown that CoQ 10 can  normal ized  Mn  SOD,  CAT  a nd GST  activities  after  Cd-induced  changes .",
publisher = "Cadiz: Univerzidad de Cadiz",
journal = "Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain",
title = "Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10",
pages = "170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6020"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z., Radojičić, R.,& Petrović, V. M.. (2003). Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10. in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain
Cadiz: Univerzidad de Cadiz., 170.
https://hdl.handle.net/21.15107/rcub_ibiss_6020

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Radojičić R, Petrović VM. Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10. in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain. 2003;:170.
https://hdl.handle.net/21.15107/rcub_ibiss_6020 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Radojičić, Ratko, Petrović, Vojislav M., "Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10" in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain (2003):170,
https://hdl.handle.net/21.15107/rcub_ibiss_6020 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5963
AB  - Cadmium (Cd) is an ubiquitous toxic metal that is involved in a variety of pathological condicions. The present study investigated the po-,sible protective role of vitamin E (Vit E) in cadmium induced oxidative stress in the blood of rats. Male, Wistar albino rats 3 months old (weighing 280 ± 30 g) were used in our experiments. Rats were injected with a single dose (1) of CdClz (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing), (2)Vit E + Cd (20 UI Vit E/kg b.m., i.m., 48h +0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The group of animals without treatment was control. The activities of enzymatic components of AOS: copper zinc containing superoxide-dismutase (CuZn SOD), catalase (CAT), glutathione-peroxidase   (GSH­
Px), glutathione-reductase (GR) and glutathione-S-transferase (GST) were  analyzed
in erythrocytes  and concentrations of non-enzymatic  components of  AOS: reduced	'
glutathione   (GSH),  ascorbic  acid  (AsA)  and  vitamin   E  (Vit  E),  as  well  as  lipid    peroxide  (LP) concentration  were determined  in the blood of rats.  Acute intoxication	I of rats with  Cd  were followed  by significantly  increased  LP  and increased activities		I
of enzymatic, as well as concentrations of non-enzymatic components of AOS in blood. The pretreatment with vitamin E after acute intoxication of rats with Cd partialy improved components of AOS. Our results indicate that liposoluble antioxidant (Vit E) resulted as suitable and potent antioxidant action, probably as consequence of quenchening of reactive oxygen species, inhibiton of lipid peroxidation and prevention of free-radical mediated injuries. The results of this study suggested that vitamin E functions as antioxygenic nutrients.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
T1  - Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E
SP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5963
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2003",
abstract = "Cadmium (Cd) is an ubiquitous toxic metal that is involved in a variety of pathological condicions. The present study investigated the po-,sible protective role of vitamin E (Vit E) in cadmium induced oxidative stress in the blood of rats. Male, Wistar albino rats 3 months old (weighing 280 ± 30 g) were used in our experiments. Rats were injected with a single dose (1) of CdClz (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing), (2)Vit E + Cd (20 UI Vit E/kg b.m., i.m., 48h +0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The group of animals without treatment was control. The activities of enzymatic components of AOS: copper zinc containing superoxide-dismutase (CuZn SOD), catalase (CAT), glutathione-peroxidase   (GSH­
Px), glutathione-reductase (GR) and glutathione-S-transferase (GST) were  analyzed
in erythrocytes  and concentrations of non-enzymatic  components of  AOS: reduced	'
glutathione   (GSH),  ascorbic  acid  (AsA)  and  vitamin   E  (Vit  E),  as  well  as  lipid    peroxide  (LP) concentration  were determined  in the blood of rats.  Acute intoxication	I of rats with  Cd  were followed  by significantly  increased  LP  and increased activities		I
of enzymatic, as well as concentrations of non-enzymatic components of AOS in blood. The pretreatment with vitamin E after acute intoxication of rats with Cd partialy improved components of AOS. Our results indicate that liposoluble antioxidant (Vit E) resulted as suitable and potent antioxidant action, probably as consequence of quenchening of reactive oxygen species, inhibiton of lipid peroxidation and prevention of free-radical mediated injuries. The results of this study suggested that vitamin E functions as antioxygenic nutrients.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia",
title = "Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E",
pages = "69",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5963"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2003). Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E. in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
Belgrade: Serbian Physiology Society., 69.
https://hdl.handle.net/21.15107/rcub_ibiss_5963

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E. in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia. 2003;:69.
https://hdl.handle.net/21.15107/rcub_ibiss_5963 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E" in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia (2003):69,
https://hdl.handle.net/21.15107/rcub_ibiss_5963 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5962
AB  - Cadmium (Cd) is a widely used industrial chemical and it is well known that Cd induces  on  oxidative  stress  that  in  oxidative  deterioration  of  biological macromolec ules. Coenzyme Q10 (CoQ10) is a lipid co-factor th at is involved in numerous enzymatic processes and is present in most cellular membranes.  Thus, CoQ1o is also important as a lipophilic regulator of oxidative stress.
The aim of this study was to investigate a possible protective influence of CoQ 10  in Cd induced oxidative stress in the rat hearts.
Male, Wistar albino rats (3 months old), injected with (I) CdCh (0.4  mg  Cd/k b.m.,i.p., 24h before the sacrificing), (2) CoQ10 + Cd (20 mg CoQ10/kg b.m., i.m., 48 before the sacrificing + 0.4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and (3) CoQ10 (20 mg CoQ10/kg b.m., i.m., 48h before the sacri ficing). Acute intoxication· of rats with Cd were  followed  by significantly  increased  of  all examined    antioxidant
defense enzymes (total SOD, Mn SOD, CnZn SOD, CAT, GSH-Px, GST and GR), while AsA and Vit E concentrations were significantly decreased. A significantly increased accumulation of Cd in heart tissue was observed· in animals treated with Cd.  These  ubiquitous  reaction·s of  Cd  result  as  its  toxic  effects  on  whole  heart  and other tissues and organs.
The protective role of CoQ1o in acute Cd intoxication results as decreased  activities  of total SOD, CuZn SOD, GSH-Px and GST. AsA concentration was also reversed to the control value. However, pretreatment with CoQ10 induced  further  increase  of CAT and GR activities and Vit E concentration. Our results showed that CoQ10 functions as a lipid-soluble antioxidant, and protects cells from  lipid  peroxidation.  The results of our study suggested that CoQ 10 functions as a potent antioxidant in protection of rat heart against oxidative stress induced by  Cd.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
T1  - Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10
SP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5962
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2003",
abstract = "Cadmium (Cd) is a widely used industrial chemical and it is well known that Cd induces  on  oxidative  stress  that  in  oxidative  deterioration  of  biological macromolec ules. Coenzyme Q10 (CoQ10) is a lipid co-factor th at is involved in numerous enzymatic processes and is present in most cellular membranes.  Thus, CoQ1o is also important as a lipophilic regulator of oxidative stress.
The aim of this study was to investigate a possible protective influence of CoQ 10  in Cd induced oxidative stress in the rat hearts.
Male, Wistar albino rats (3 months old), injected with (I) CdCh (0.4  mg  Cd/k b.m.,i.p., 24h before the sacrificing), (2) CoQ10 + Cd (20 mg CoQ10/kg b.m., i.m., 48 before the sacrificing + 0.4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and (3) CoQ10 (20 mg CoQ10/kg b.m., i.m., 48h before the sacri ficing). Acute intoxication· of rats with Cd were  followed  by significantly  increased  of  all examined    antioxidant
defense enzymes (total SOD, Mn SOD, CnZn SOD, CAT, GSH-Px, GST and GR), while AsA and Vit E concentrations were significantly decreased. A significantly increased accumulation of Cd in heart tissue was observed· in animals treated with Cd.  These  ubiquitous  reaction·s of  Cd  result  as  its  toxic  effects  on  whole  heart  and other tissues and organs.
The protective role of CoQ1o in acute Cd intoxication results as decreased  activities  of total SOD, CuZn SOD, GSH-Px and GST. AsA concentration was also reversed to the control value. However, pretreatment with CoQ10 induced  further  increase  of CAT and GR activities and Vit E concentration. Our results showed that CoQ10 functions as a lipid-soluble antioxidant, and protects cells from  lipid  peroxidation.  The results of our study suggested that CoQ 10 functions as a potent antioxidant in protection of rat heart against oxidative stress induced by  Cd.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia",
title = "Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10",
pages = "68",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5962"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2003). Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10. in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
Belgrade: Serbian Physiology Society., 68.
https://hdl.handle.net/21.15107/rcub_ibiss_5962

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10. in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia. 2003;:68.
https://hdl.handle.net/21.15107/rcub_ibiss_5962 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10" in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia (2003):68,
https://hdl.handle.net/21.15107/rcub_ibiss_5962 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6118
AB  - In our experiments male two months old Wistar albino rats were used. In the experim with acute Cd intoxication animals were injected with  (1)  Cd  (0.4  mg  CdCh/kg  b.m.,  i.p., before the sacrificing), (2) Vitamin E+Coenzyme  Q10+Cd (20  IU Vit E/kg  b.m .,  i.m. , 48h be the  sacrificing+  20  mg  CoQ10/kg  b.m.,  i.m.,  48h before  the sacrificing+  0.4  mg  CdCb/kg b i p., 24h before the sacrificing). Third group (3) was control  (C).  In  the experiment  with chro Cd intoxication the animals were treated as follov,s: (1) Cd (14 mg/day/kg b.m. CdCb in drink water during 15 days (Cd), (2) Vit E+CoQ 1o+Cd (pretreated with 20 IU/kg/dose of Vit E and mg/kg/dose  of  CoQ10  i.m., every  fifth day during  15 days  and  then  treated  with  14   mg/day b.m. of Cd during next 15 days Third group (3) was control (C). After the treatment the rats w sacrificed by decapitation and blood samples were collected and analyzed. In the blood of rats conce ntration of lipide peroxides (LP) were evaluated, while the activity  of  gluta tione transferase was assayed in the plasma after separation from the    blood cells.
The results obtained in our experiments show that acute treatment with Cd leads to significantly increased LP concentration (p<0.01) in the blood of rats in respect to the con animals. Pretreatment  with  Vit  E+CoQ 10  pryor  to  Cd exposure  normalyzed  the concentration LP   in   the· blood.   Contrary   to   that,   in   chronic   Cd   intoxication   concentration   of LP significantly   decreased   (p<0.005)   in   comparison   to   the   control   value.   Pretreatment   Vit E+CoQ 10 pryor to Cd intoxication influences an additional decrease of LP concentra (p<0.005) compared with controls. It appears that in chronic Cd treatment the period of 15 day sufficient for the development of efficient red blood cell protection against Cd (per)oxida  damage. The activity of GST in the plasma of rats acutely treated with Cd was  signi fica  increased in respect to the controls (p<0.02). Pretreatment of rats with Vit E+CoQ 10 influenc significant decrease of GST activity in the plasma (p<0.05).  Similar  results  were  obtained chronic Cd intoxication where Cd induces a significantly higher activity of GST in the pla (p<0.01), while pretreatment  with Vit E+CoQ 10 reversed this value to the control   level.
From  the   presented   results,  it  can  be  concluded   that  Cd   both   in  acute  and  chr
intoxication influences blood LP concentration and plasma GST activi ty . Pretreatment antioxidants, such as Vit E and CoQ 10 diminishes the toxi c effects of Cd on both evalu parameters. At the same time, we were also noticed a different mechanisms of defence against toxicity in acute and in chronic intoxication, especially in the case of blood LP con cen tration.
PB  - Morgantown: National Institute for Occupational Safety and Health
C3  - 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA
T1  - Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication
SP  - P11
EP  - P11
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6118
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2002",
abstract = "In our experiments male two months old Wistar albino rats were used. In the experim with acute Cd intoxication animals were injected with  (1)  Cd  (0.4  mg  CdCh/kg  b.m.,  i.p., before the sacrificing), (2) Vitamin E+Coenzyme  Q10+Cd (20  IU Vit E/kg  b.m .,  i.m. , 48h be the  sacrificing+  20  mg  CoQ10/kg  b.m.,  i.m.,  48h before  the sacrificing+  0.4  mg  CdCb/kg b i p., 24h before the sacrificing). Third group (3) was control  (C).  In  the experiment  with chro Cd intoxication the animals were treated as follov,s: (1) Cd (14 mg/day/kg b.m. CdCb in drink water during 15 days (Cd), (2) Vit E+CoQ 1o+Cd (pretreated with 20 IU/kg/dose of Vit E and mg/kg/dose  of  CoQ10  i.m., every  fifth day during  15 days  and  then  treated  with  14   mg/day b.m. of Cd during next 15 days Third group (3) was control (C). After the treatment the rats w sacrificed by decapitation and blood samples were collected and analyzed. In the blood of rats conce ntration of lipide peroxides (LP) were evaluated, while the activity  of  gluta tione transferase was assayed in the plasma after separation from the    blood cells.
The results obtained in our experiments show that acute treatment with Cd leads to significantly increased LP concentration (p<0.01) in the blood of rats in respect to the con animals. Pretreatment  with  Vit  E+CoQ 10  pryor  to  Cd exposure  normalyzed  the concentration LP   in   the· blood.   Contrary   to   that,   in   chronic   Cd   intoxication   concentration   of LP significantly   decreased   (p<0.005)   in   comparison   to   the   control   value.   Pretreatment   Vit E+CoQ 10 pryor to Cd intoxication influences an additional decrease of LP concentra (p<0.005) compared with controls. It appears that in chronic Cd treatment the period of 15 day sufficient for the development of efficient red blood cell protection against Cd (per)oxida  damage. The activity of GST in the plasma of rats acutely treated with Cd was  signi fica  increased in respect to the controls (p<0.02). Pretreatment of rats with Vit E+CoQ 10 influenc significant decrease of GST activity in the plasma (p<0.05).  Similar  results  were  obtained chronic Cd intoxication where Cd induces a significantly higher activity of GST in the pla (p<0.01), while pretreatment  with Vit E+CoQ 10 reversed this value to the control   level.
From  the   presented   results,  it  can  be  concluded   that  Cd   both   in  acute  and  chr
intoxication influences blood LP concentration and plasma GST activi ty . Pretreatment antioxidants, such as Vit E and CoQ 10 diminishes the toxi c effects of Cd on both evalu parameters. At the same time, we were also noticed a different mechanisms of defence against toxicity in acute and in chronic intoxication, especially in the case of blood LP con cen tration.",
publisher = "Morgantown: National Institute for Occupational Safety and Health",
journal = "2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA",
title = "Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication",
pages = "P11-P11",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6118"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z., Radojičić, R.,& Petrović, V. M.. (2002). Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication. in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA
Morgantown: National Institute for Occupational Safety and Health., P11-P11.
https://hdl.handle.net/21.15107/rcub_ibiss_6118

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Radojičić R, Petrović VM. Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication. in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA. 2002;:P11-P11.
https://hdl.handle.net/21.15107/rcub_ibiss_6118 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Radojičić, Ratko, Petrović, Vojislav M., "Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication" in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA (2002):P11-P11,
https://hdl.handle.net/21.15107/rcub_ibiss_6118 .

TY  - CONF
AU  - Velkovski, Saško
AU  - Ristić, Snežana
AU  - Milošević, Verica
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
AU  - Pavlović, Slađan
AU  - Nikolić, Aleksandra
AU  - Blagojević, Duško
AU  - Starčević, Vesna
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5958
AB  - Postoji veli ki broj podataka o pokusajima uspostavljanja pouzdanog animalnog modela atcroskleroze, ali jos n ije poznat  dovoljno  dobar  analog  humanoj  aterosk lerozi. Kao prilog ovim is trazivanjima, pokusali smo da proce­ nimo doprinos  reaktivnih  vrsta  kiseonika  (ROS)  u  ranoj ate rogenezi i  prevcntivnu  ulogu  cndogenog  antioksida ­ cio nog zastitnog sis tema (AOS). Odrasli muzjaci Wistar albin o pacova, te les ne masc  oko  400  g,  korisceni  su  za sp rovodenje specijalne ate rogenc dijctc  koja se sas toja la od  smcse  masti  ( buter,  holesterol)  i  drugih   sup stanc i ( ho ln a kise li na, holi n hlorid, tiourac i l ). Kontrolnc i eks­ per imenta lne zivo tin je su bi le srnestcne u plasticne  ka­ veze  i  imale  s u  dostu pne  peleti ranu   hranu  i  vodu po volji. Eksperimentalne zivotinje su dobijale svakoga dana u toku 8 nedeija po 5 g aterogene smese, sondom, intragastricno. Na  kraju  dijete  sve zivotinje  su zrtvovane i sakupljena je krv za odredivanje (1) lipidnog statusa: koncentracija triglicerida (TG), ukupnog holesterola (CH). LDL holesterola i HDL holesterola u plazmi, od­ nosa  koncentracija  LDL i HDL  holesterola  (LDL/HDL) i (2) antioksidacionog statusa u krvi: aktivnost kata­ laze u eritrocitima (Er CAT), aktivnost glutation-S-tran­ sferaze (GST) u  plazmi,  koncentracija  glutationa  (GSH) u plazmi i koncentracija vitamina E (Vit. E) u plazmi. Uzimani su isecci abdominalne aorte za histolosku veri­ fikaciju ateroskle roze. Razlike izmedu vrednosti kon­ trolnih i eksperimentalnih zivotinja testirane su  stati­ sticki.
Analiza hitoloskih praparata aorte pokazala je normalnu gradu arterijskog zida u kontrolnih zivotinja , dok su u eksperimentalnih zivotinja nadene inicijalne promene u intimi (zadebljanje i  celijska akumulacija). Vrednosti svih pracenih varijabli lipidnog i  antioksidacionog  sta­ tusa u kontrolnih zivotinja bile su normalne. U eksperi­ inentalnih zivotinja postojalo je statisticki znacajno po­ vecanje koncentracije TG  (p < 0,05),  koncentracije  CH (p < 0,01), koncentracije LDL (p < 0,01) i odnosa LDL/HDL (p < 0,01) u poredenju sa kontrolnim zivoti­ njama . Koncentracija HDL bila je nepromenjena (p > 0,05). Aktivnost Er CAT i koncentracija  GSH  u plazmi bile su povecane  u  eksperimentalnih  zivotinja  u odnosu na kontrolne,  ali  ne znacajno (p > 0,05). Aktivnost  GST  u plazmi nije bila promenjena (p > 0,05). Samo kon­ centracija Vit. E u  plazmi eksperimentalnih  zivotinja bila je statisticki znacajno veca  u poredenju  sa  kontrol­ nim zivotinjama (p < 0,01). Mozemo zakljuciti da anti­ oksidacioni status u krvi nije bio u korelaciji sa lipidnim statusom  u toku rane aterogeneze  u odraslih  pacova.
PB  - Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
C3  - Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
T1  - Lipidni i antioksidacioni status u animalnom modelu eksperimentalne ateroskleroze
SP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5958
ER  - 

@conference{
author = "Velkovski, Saško and Ristić, Snežana and Milošević, Verica and Saičić, Zorica and Spasić, Mihajlo and Pavlović, Slađan and Nikolić, Aleksandra and Blagojević, Duško and Starčević, Vesna",
year = "2002",
abstract = "Postoji veli ki broj podataka o pokusajima uspostavljanja pouzdanog animalnog modela atcroskleroze, ali jos n ije poznat  dovoljno  dobar  analog  humanoj  aterosk lerozi. Kao prilog ovim is trazivanjima, pokusali smo da proce­ nimo doprinos  reaktivnih  vrsta  kiseonika  (ROS)  u  ranoj ate rogenezi i  prevcntivnu  ulogu  cndogenog  antioksida ­ cio nog zastitnog sis tema (AOS). Odrasli muzjaci Wistar albin o pacova, te les ne masc  oko  400  g,  korisceni  su  za sp rovodenje specijalne ate rogenc dijctc  koja se sas toja la od  smcse  masti  ( buter,  holesterol)  i  drugih   sup stanc i ( ho ln a kise li na, holi n hlorid, tiourac i l ). Kontrolnc i eks­ per imenta lne zivo tin je su bi le srnestcne u plasticne  ka­ veze  i  imale  s u  dostu pne  peleti ranu   hranu  i  vodu po volji. Eksperimentalne zivotinje su dobijale svakoga dana u toku 8 nedeija po 5 g aterogene smese, sondom, intragastricno. Na  kraju  dijete  sve zivotinje  su zrtvovane i sakupljena je krv za odredivanje (1) lipidnog statusa: koncentracija triglicerida (TG), ukupnog holesterola (CH). LDL holesterola i HDL holesterola u plazmi, od­ nosa  koncentracija  LDL i HDL  holesterola  (LDL/HDL) i (2) antioksidacionog statusa u krvi: aktivnost kata­ laze u eritrocitima (Er CAT), aktivnost glutation-S-tran­ sferaze (GST) u  plazmi,  koncentracija  glutationa  (GSH) u plazmi i koncentracija vitamina E (Vit. E) u plazmi. Uzimani su isecci abdominalne aorte za histolosku veri­ fikaciju ateroskle roze. Razlike izmedu vrednosti kon­ trolnih i eksperimentalnih zivotinja testirane su  stati­ sticki.
Analiza hitoloskih praparata aorte pokazala je normalnu gradu arterijskog zida u kontrolnih zivotinja , dok su u eksperimentalnih zivotinja nadene inicijalne promene u intimi (zadebljanje i  celijska akumulacija). Vrednosti svih pracenih varijabli lipidnog i  antioksidacionog  sta­ tusa u kontrolnih zivotinja bile su normalne. U eksperi­ inentalnih zivotinja postojalo je statisticki znacajno po­ vecanje koncentracije TG  (p < 0,05),  koncentracije  CH (p < 0,01), koncentracije LDL (p < 0,01) i odnosa LDL/HDL (p < 0,01) u poredenju sa kontrolnim zivoti­ njama . Koncentracija HDL bila je nepromenjena (p > 0,05). Aktivnost Er CAT i koncentracija  GSH  u plazmi bile su povecane  u  eksperimentalnih  zivotinja  u odnosu na kontrolne,  ali  ne znacajno (p > 0,05). Aktivnost  GST  u plazmi nije bila promenjena (p > 0,05). Samo kon­ centracija Vit. E u  plazmi eksperimentalnih  zivotinja bila je statisticki znacajno veca  u poredenju  sa  kontrol­ nim zivotinjama (p < 0,01). Mozemo zakljuciti da anti­ oksidacioni status u krvi nije bio u korelaciji sa lipidnim statusom  u toku rane aterogeneze  u odraslih  pacova.",
publisher = "Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo",
journal = "Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia",
title = "Lipidni i antioksidacioni status u animalnom modelu eksperimentalne ateroskleroze",
pages = "64",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5958"
}

Velkovski, S., Ristić, S., Milošević, V., Saičić, Z., Spasić, M., Pavlović, S., Nikolić, A., Blagojević, D.,& Starčević, V.. (2002). Lipidni i antioksidacioni status u animalnom modelu eksperimentalne ateroskleroze. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo., 64.
https://hdl.handle.net/21.15107/rcub_ibiss_5958

Velkovski S, Ristić S, Milošević V, Saičić Z, Spasić M, Pavlović S, Nikolić A, Blagojević D, Starčević V. Lipidni i antioksidacioni status u animalnom modelu eksperimentalne ateroskleroze. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. 2002;:64.
https://hdl.handle.net/21.15107/rcub_ibiss_5958 .

Velkovski, Saško, Ristić, Snežana, Milošević, Verica, Saičić, Zorica, Spasić, Mihajlo, Pavlović, Slađan, Nikolić, Aleksandra, Blagojević, Duško, Starčević, Vesna, "Lipidni i antioksidacioni status u animalnom modelu eksperimentalne ateroskleroze" in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia (2002):64,
https://hdl.handle.net/21.15107/rcub_ibiss_5958 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5959
AB  - Cadmium induced lipid peroxidation (LPO) and altering the antioxidant system after the administration  of a sin­ gle dose of CdCl2 (0.4 mg /kg body wt, i.p., 24 hours before the sacrificing) was studied in the blood of rats.  The protect ive role of coenzyme Q (20 mg  CoQ10/kg body wt, i.m., 48 hours before the sacrificing) and vita­ min E (20 iu Vit E/kg body wt, i. m., 48 hours before the sacrificing) was also studied in  the  blood  of  rats after the acute intoxication with cadmium.  The  treatment with Cd increased LPO in the blood while animals pre­ treated with coenzyme Q and/or vitamin E prior to Cd treatment showed decreased LPO as compared with animals  given  Cd  alone.  Activities  of  superoxide dismu­tase   (SOD),   catalase   (CATt,  glutathion  e peroxidase (GS H-Px) and  glut athione  reductas e  (GR)  in  erythro­cytes  and  activities  glutathione  S-transferase   (GST)   as well   as  concentrations  ascorbic   acid  (AsA)  and   vitamin E (Vit E) in the plasma were significantly incr eased of Cd  and  CoQ 10   treated  rats  (p<0.05  or  Jess).  The  pre­ treatment  with  coen zyme  Q  and/or  vitamin   E  prior  to  Cd administration partially reversed such  changes.  In animals  treatment  with  antioxidants prior  to   Cd   treat­ment  decreased  significantly   activiti es   of   SOD,   CAT and GR in erythrocytes, and activity GST and concen­trations AsA in the plasma  and  were  the  same  as  con­  trols  values.  However, the  pretreatment with  coenzyme Q and/or vitamin E prior to Cd administration showed increased  erythrocyte  GSH-Px  activity  and  concentra­tions vit amin E in the plasma as compared  with  animals given Cd alone. The results sugges that Cd int oxic ation induces oxidative stress and  alters  the  antioxidant sys­tem, resulting  in  increased  lipid  peroxidation  to  rat erythrocytes. Coenzyme Q and vitamin  E are the  power­ful liposoluble antioxidants which in cells quenched free oxygen radicals, inhibit lipid peroxidation and  thus  pre­vent free-radical mediated oxidant  injuries.  It  is  known that coenzyme Q and vitamin E may act sinergically as antioxidanrs. The pretreatment with coenzyme Q and /or vitamin E prior to Cd treatment showed protective effect against  toxic  influence  of  Cd  on  peroxidation  of  mem­ brane lipids and  altering  the  antioxidant  system  in  the blood  of rats.
PB  - Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
C3  - Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
T1  - Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium
SP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5959
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2002",
abstract = "Cadmium induced lipid peroxidation (LPO) and altering the antioxidant system after the administration  of a sin­ gle dose of CdCl2 (0.4 mg /kg body wt, i.p., 24 hours before the sacrificing) was studied in the blood of rats.  The protect ive role of coenzyme Q (20 mg  CoQ10/kg body wt, i.m., 48 hours before the sacrificing) and vita­ min E (20 iu Vit E/kg body wt, i. m., 48 hours before the sacrificing) was also studied in  the  blood  of  rats after the acute intoxication with cadmium.  The  treatment with Cd increased LPO in the blood while animals pre­ treated with coenzyme Q and/or vitamin E prior to Cd treatment showed decreased LPO as compared with animals  given  Cd  alone.  Activities  of  superoxide dismu­tase   (SOD),   catalase   (CATt,  glutathion  e peroxidase (GS H-Px) and  glut athione  reductas e  (GR)  in  erythro­cytes  and  activities  glutathione  S-transferase   (GST)   as well   as  concentrations  ascorbic   acid  (AsA)  and   vitamin E (Vit E) in the plasma were significantly incr eased of Cd  and  CoQ 10   treated  rats  (p<0.05  or  Jess).  The  pre­ treatment  with  coen zyme  Q  and/or  vitamin   E  prior  to  Cd administration partially reversed such  changes.  In animals  treatment  with  antioxidants prior  to   Cd   treat­ment  decreased  significantly   activiti es   of   SOD,   CAT and GR in erythrocytes, and activity GST and concen­trations AsA in the plasma  and  were  the  same  as  con­  trols  values.  However, the  pretreatment with  coenzyme Q and/or vitamin E prior to Cd administration showed increased  erythrocyte  GSH-Px  activity  and  concentra­tions vit amin E in the plasma as compared  with  animals given Cd alone. The results sugges that Cd int oxic ation induces oxidative stress and  alters  the  antioxidant sys­tem, resulting  in  increased  lipid  peroxidation  to  rat erythrocytes. Coenzyme Q and vitamin  E are the  power­ful liposoluble antioxidants which in cells quenched free oxygen radicals, inhibit lipid peroxidation and  thus  pre­vent free-radical mediated oxidant  injuries.  It  is  known that coenzyme Q and vitamin E may act sinergically as antioxidanrs. The pretreatment with coenzyme Q and /or vitamin E prior to Cd treatment showed protective effect against  toxic  influence  of  Cd  on  peroxidation  of  mem­ brane lipids and  altering  the  antioxidant  system  in  the blood  of rats.",
publisher = "Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo",
journal = "Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia",
title = "Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium",
pages = "70",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5959"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2002). Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo., 70.
https://hdl.handle.net/21.15107/rcub_ibiss_5959

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. 2002;:70.
https://hdl.handle.net/21.15107/rcub_ibiss_5959 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium" in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia (2002):70,
https://hdl.handle.net/21.15107/rcub_ibiss_5959 .

TY  - CONF
AU  - Marković, Mirjana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Ognjanović, Branka
AU  - Saičić, Zorica
AU  - Pavlović, Slađan
AU  - Radojičić, Ratko
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5961
AB  - In our experiments conunon carps (Cyprinus carpio   L.) were    acclimated    to    an    oxygen    concentration  of 7.3 lmg/L water (100%) - control (C) group. Two ex­ perimental groups (H1, H2) were exposed to acute hy­ poxia. One of them was exposed to a progressive reduc­tion of 02 to 4.1 O2 mg/L (55%) for 1 ¼ hour s and another 1.95mg/L (25%) for 2 hours, respectively. The fourth experimental group (HP) was exposed to a progressive increase of oxygen concentration O2 to 10 mg/L (150%) for I5 minutes, respectively. In our exper iment was determinated antioxidant defense· s yste m enzymes activity (superoxide-dismutase   (SOD),   catalase   (CAT) glutathione-peroxidase (GSH-Px) , and glutathione-reductase (GR) and glutathione-S-transferase (GST) ac­ tivity (Misra, H.P. and Fridovich, I. (19 72), Beutler (1982), Tamure et al. ( I982), Habig et  al.  (1974), Glatzle et  al. (1974).
Our  res ult s  show  that  stress  caused  by  acute  hypoxia and hyperoxia significantly changes the activities of antioxidant defense system enzymes, superoxide-dis­mutase   (SOD),  glutathione-peroxidase   (GSH-Px),   and glutathione-reductase (GR) in carps gills. Acute pro­ longed hypoxia (H2) caused a cetrain  degree  of  adapta­tion in respect  to  catalase  (CAT)  and  glutathione-S­ transferase  (GST) activity .
PB  - Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
C3  - Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
T1  - Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)
SP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5961
ER  - 

@conference{
author = "Marković, Mirjana and Žikić, Radoslav V. and Štajn, Andraš Š. and Ognjanović, Branka and Saičić, Zorica and Pavlović, Slađan and Radojičić, Ratko",
year = "2002",
abstract = "In our experiments conunon carps (Cyprinus carpio   L.) were    acclimated    to    an    oxygen    concentration  of 7.3 lmg/L water (100%) - control (C) group. Two ex­ perimental groups (H1, H2) were exposed to acute hy­ poxia. One of them was exposed to a progressive reduc­tion of 02 to 4.1 O2 mg/L (55%) for 1 ¼ hour s and another 1.95mg/L (25%) for 2 hours, respectively. The fourth experimental group (HP) was exposed to a progressive increase of oxygen concentration O2 to 10 mg/L (150%) for I5 minutes, respectively. In our exper iment was determinated antioxidant defense· s yste m enzymes activity (superoxide-dismutase   (SOD),   catalase   (CAT) glutathione-peroxidase (GSH-Px) , and glutathione-reductase (GR) and glutathione-S-transferase (GST) ac­ tivity (Misra, H.P. and Fridovich, I. (19 72), Beutler (1982), Tamure et al. ( I982), Habig et  al.  (1974), Glatzle et  al. (1974).
Our  res ult s  show  that  stress  caused  by  acute  hypoxia and hyperoxia significantly changes the activities of antioxidant defense system enzymes, superoxide-dis­mutase   (SOD),  glutathione-peroxidase   (GSH-Px),   and glutathione-reductase (GR) in carps gills. Acute pro­ longed hypoxia (H2) caused a cetrain  degree  of  adapta­tion in respect  to  catalase  (CAT)  and  glutathione-S­ transferase  (GST) activity .",
publisher = "Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo",
journal = "Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia",
title = "Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)",
pages = "71",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5961"
}

Marković, M., Žikić, R. V., Štajn, A. Š., Ognjanović, B., Saičić, Z., Pavlović, S.,& Radojičić, R.. (2002). Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.). in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo., 71.
https://hdl.handle.net/21.15107/rcub_ibiss_5961

Marković M, Žikić RV, Štajn AŠ, Ognjanović B, Saičić Z, Pavlović S, Radojičić R. Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.). in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. 2002;:71.
https://hdl.handle.net/21.15107/rcub_ibiss_5961 .

Marković, Mirjana, Žikić, Radoslav V., Štajn, Andraš Š., Ognjanović, Branka, Saičić, Zorica, Pavlović, Slađan, Radojičić, Ratko, "Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)" in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia (2002):71,
https://hdl.handle.net/21.15107/rcub_ibiss_5961 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Maletić, Snežana
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5936
AB  - Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.
PB  - International Coenzyme Q10 Association
C3  - Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
T1  - The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats
SP  - 167
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5936
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Maletić, Snežana and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2002",
abstract = "Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.",
publisher = "International Coenzyme Q10 Association",
journal = "Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom",
title = "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats",
pages = "167-169",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5936"
}

Ognjanović, B., Pavlović, S., Žikić, R. V., Štajn, A. Š., Saičić, Z., Maletić, S., Radojičić, R.,& Petrović, V. M.. (2002). The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
International Coenzyme Q10 Association., 167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936

Ognjanović B, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z, Maletić S, Radojičić R, Petrović VM. The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom. 2002;:167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

Ognjanović, Branka, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Maletić, Snežana, Radojičić, Ratko, Petrović, Vojislav M., "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats" in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom (2002):167-169,
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

TY  - CONF
AU  - Žikić, Radoslav V.
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5916
AB  - Postojeci medjunarodni propisi, standardi i direktive koji se odnose na kvalitet harne su dobrim delom ugradjeni u jugoslovensko zakonodavstvo i propise. Njihovo dosledno postovanje je neophodno ne  samo zbog zadovoljenja kvaliteta hrane koja se distribuira na domacem tzistu vec je i preduslov nase uspesne izvome orijemacije i konkurenmosti na inostranom trzistu prehrambenih proizvoda. Istrazivanja oksidacione stabilnosti hrane koja se sprovode u mnogim istrazivackim laboratorijama u svetu namecu potrebu uvodjenja novih kriterijuma i standarda koji bi obuhvatili i odredjivanje antioksidacionih komponenata u hrani. Rezultati dobijeni u nasim istrazivanjima pokazuju da naknadnim dodavanjem pojedinih komponenata antioksidacionog sistema (selen) moze znacajno da se poveca ukupni nivo ostalih antioksidanata u tkivima eksperimentalnih zivotinja.
PB  - Zaječar : Organizacioni odbor "Ekološke istine 2002"
C3  - Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia
T1  - Biološki značaj selena - važan faktor visoko kvalitetne hrane
SP  - 157
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5916
ER  - 

@conference{
author = "Žikić, Radoslav V. and Ognjanović, Branka and Štajn, Andraš Š. and Pavlović, Slađan and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
abstract = "Postojeci medjunarodni propisi, standardi i direktive koji se odnose na kvalitet harne su dobrim delom ugradjeni u jugoslovensko zakonodavstvo i propise. Njihovo dosledno postovanje je neophodno ne  samo zbog zadovoljenja kvaliteta hrane koja se distribuira na domacem tzistu vec je i preduslov nase uspesne izvome orijemacije i konkurenmosti na inostranom trzistu prehrambenih proizvoda. Istrazivanja oksidacione stabilnosti hrane koja se sprovode u mnogim istrazivackim laboratorijama u svetu namecu potrebu uvodjenja novih kriterijuma i standarda koji bi obuhvatili i odredjivanje antioksidacionih komponenata u hrani. Rezultati dobijeni u nasim istrazivanjima pokazuju da naknadnim dodavanjem pojedinih komponenata antioksidacionog sistema (selen) moze znacajno da se poveca ukupni nivo ostalih antioksidanata u tkivima eksperimentalnih zivotinja.",
publisher = "Zaječar : Organizacioni odbor "Ekološke istine 2002"",
journal = "Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia",
title = "Biološki značaj selena - važan faktor visoko kvalitetne hrane",
pages = "157-160",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5916"
}

Žikić, R. V., Ognjanović, B., Štajn, A. Š., Pavlović, S., Saičić, Z.,& Petrović, V. M.. (2002). Biološki značaj selena - važan faktor visoko kvalitetne hrane. in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia
Zaječar : Organizacioni odbor "Ekološke istine 2002"., 157-160.
https://hdl.handle.net/21.15107/rcub_ibiss_5916

Žikić RV, Ognjanović B, Štajn AŠ, Pavlović S, Saičić Z, Petrović VM. Biološki značaj selena - važan faktor visoko kvalitetne hrane. in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia. 2002;:157-160.
https://hdl.handle.net/21.15107/rcub_ibiss_5916 .

Žikić, Radoslav V., Ognjanović, Branka, Štajn, Andraš Š., Pavlović, Slađan, Saičić, Zorica, Petrović, Vojislav M., "Biološki značaj selena - važan faktor visoko kvalitetne hrane" in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia (2002):157-160,
https://hdl.handle.net/21.15107/rcub_ibiss_5916 .

TY  - JOUR
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Mihajlović, Ranđel P.
AU  - Mandić, Sreten
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://www.studiamarina.ac.me/pdf/23/MUSSELS%20AS%20BIOIDICATORS%20OF%20PRESENCE%20OF%20HEAVY%20METALS%20IN%20BOKA%20KOTORSKA%20BAY.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5900
AB  - Rapid  urbanization  and  eutrophization,  disturbing  normal  ecological equilibrium of water ecosystems and directly endangering living organisms is the main problem in Boka Kotorska bay. Mediterranean mussel (Mytilus galloprovincialis, Bivalvia, Mollusca) is a species which naturally inhabits the waters of Boka Kotorska bay, but it is artificially bred and increasingly used in human diet. We established that the presence of heavy metals in sea water even in allowed concentrations caused increased accumulation in tissues of mussel (Cu, Mn, Cr, Ni, Al, Mg, Zn, Cd, Pb) pointing to a numerous negative consequences not only in those organisms but in humans, potential consumers of mussels as well.
PB  - Kotor: Institute of Marine Biology, University of Montenegro
T2  - Studia Marina
T1  - Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu
T1  - Mussels (Mytilus galloprovincialis) as bioindicators of presence of heavy metals in Boka Kotorska Bay
IS  - 1
VL  - 23
SP  - 87
EP  - 94
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5900
ER  - 

@article{
author = "Štajn, Andraš Š. and Žikić, Radoslav V. and Mihajlović, Ranđel P. and Mandić, Sreten and Ognjanović, Branka and Pavlović, Slađan and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
abstract = "Rapid  urbanization  and  eutrophization,  disturbing  normal  ecological equilibrium of water ecosystems and directly endangering living organisms is the main problem in Boka Kotorska bay. Mediterranean mussel (Mytilus galloprovincialis, Bivalvia, Mollusca) is a species which naturally inhabits the waters of Boka Kotorska bay, but it is artificially bred and increasingly used in human diet. We established that the presence of heavy metals in sea water even in allowed concentrations caused increased accumulation in tissues of mussel (Cu, Mn, Cr, Ni, Al, Mg, Zn, Cd, Pb) pointing to a numerous negative consequences not only in those organisms but in humans, potential consumers of mussels as well.",
publisher = "Kotor: Institute of Marine Biology, University of Montenegro",
journal = "Studia Marina",
title = "Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu, Mussels (Mytilus galloprovincialis) as bioindicators of presence of heavy metals in Boka Kotorska Bay",
number = "1",
volume = "23",
pages = "87-94",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5900"
}

Štajn, A. Š., Žikić, R. V., Mihajlović, R. P., Mandić, S., Ognjanović, B., Pavlović, S., Saičić, Z.,& Petrović, V. M.. (2002). Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu. in Studia Marina
Kotor: Institute of Marine Biology, University of Montenegro., 23(1), 87-94.
https://hdl.handle.net/21.15107/rcub_ibiss_5900

Štajn AŠ, Žikić RV, Mihajlović RP, Mandić S, Ognjanović B, Pavlović S, Saičić Z, Petrović VM. Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu. in Studia Marina. 2002;23(1):87-94.
https://hdl.handle.net/21.15107/rcub_ibiss_5900 .

Štajn, Andraš Š., Žikić, Radoslav V., Mihajlović, Ranđel P., Mandić, Sreten, Ognjanović, Branka, Pavlović, Slađan, Saičić, Zorica, Petrović, Vojislav M., "Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu" in Studia Marina, 23, no. 1 (2002):87-94,
https://hdl.handle.net/21.15107/rcub_ibiss_5900 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6119
AB  - Coenzyme Q (CoQ) is present in almost all living organisms where it exhibits antioxidant properties and also represents an obligatory component of the mitochondrial respiratory chain (2). CoQ may prevent lipide peroxidation, protects DNA from oxidation and protects organism from oxidative stress induced by various toxic agents (1). The scope of our study was to investigate the concentrations of  ascorbic acid (AsA) and vitamin  E (Vit E) in the liver, kidneys, heart and testes,   as well as CoQ concentration in the liver, kidneys and testes of male, two months old Wistar albino rats treated with 20 mg/kg of coenzyme Q10 (CoQ10) dissolved in olive oil, i.m., every fifth  day, during 30 days. An average intake of CoQ10 was 16 mg/kg/dose. All  obtained  results  were  compared with control animals  (C).
Our results show that treatment with CoQ10 induced a significant increase of AsA and Vit E concentrations in all investigated tissues. The concentration  of  CoQ  was  significantly  increased only in the liver of rats treated with CoQ10. It is well known that CoQ10 in  its  reduced  form (CoQ10H2) is the powerful antioxidant which regenerate the active form of Vit E from the Vit E radicals (tocopheroxyl radicals, Vit E"), (4), stabilized extracellular ascorbate by its NADPH-CoQ10 reductase (3) and elevate the endogenous CoQ pool in the cells (1). At the other hand, dose and time dependent studies were shown that CoQ concentration after parenteral administration was increased only in the plasma and liver ofrats  (5).It can be concluded that all obtained  effects induced by CoQ10  led to the elevated concentrations  of non-enzymatic components of antioxidant defense system and increased antioxidant protection of all examined tissues.
PB  - IUPs New Zealand
C3  - 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand
T1  - Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10
SP  - 1163
EP  - 1163
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6119
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Petrović, Vojislav M. and Saičić, Zorica and Štajn, Andraš Š. and Žikić, Radoslav V.",
year = "2001",
abstract = "Coenzyme Q (CoQ) is present in almost all living organisms where it exhibits antioxidant properties and also represents an obligatory component of the mitochondrial respiratory chain (2). CoQ may prevent lipide peroxidation, protects DNA from oxidation and protects organism from oxidative stress induced by various toxic agents (1). The scope of our study was to investigate the concentrations of  ascorbic acid (AsA) and vitamin  E (Vit E) in the liver, kidneys, heart and testes,   as well as CoQ concentration in the liver, kidneys and testes of male, two months old Wistar albino rats treated with 20 mg/kg of coenzyme Q10 (CoQ10) dissolved in olive oil, i.m., every fifth  day, during 30 days. An average intake of CoQ10 was 16 mg/kg/dose. All  obtained  results  were  compared with control animals  (C).
Our results show that treatment with CoQ10 induced a significant increase of AsA and Vit E concentrations in all investigated tissues. The concentration  of  CoQ  was  significantly  increased only in the liver of rats treated with CoQ10. It is well known that CoQ10 in  its  reduced  form (CoQ10H2) is the powerful antioxidant which regenerate the active form of Vit E from the Vit E radicals (tocopheroxyl radicals, Vit E"), (4), stabilized extracellular ascorbate by its NADPH-CoQ10 reductase (3) and elevate the endogenous CoQ pool in the cells (1). At the other hand, dose and time dependent studies were shown that CoQ concentration after parenteral administration was increased only in the plasma and liver ofrats  (5).It can be concluded that all obtained  effects induced by CoQ10  led to the elevated concentrations  of non-enzymatic components of antioxidant defense system and increased antioxidant protection of all examined tissues.",
publisher = "IUPs New Zealand",
journal = "34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand",
title = "Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10",
pages = "1163-1163",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6119"
}

Ognjanović, B., Pavlović, S., Petrović, V. M., Saičić, Z., Štajn, A. Š.,& Žikić, R. V.. (2001). Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10. in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand
IUPs New Zealand., 1163-1163.
https://hdl.handle.net/21.15107/rcub_ibiss_6119

Ognjanović B, Pavlović S, Petrović VM, Saičić Z, Štajn AŠ, Žikić RV. Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10. in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand. 2001;:1163-1163.
https://hdl.handle.net/21.15107/rcub_ibiss_6119 .

Ognjanović, Branka, Pavlović, Slađan, Petrović, Vojislav M., Saičić, Zorica, Štajn, Andraš Š., Žikić, Radoslav V., "Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10" in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand (2001):1163-1163,
https://hdl.handle.net/21.15107/rcub_ibiss_6119 .

TY  - CONF
AU  - Saičić, Zorica
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6117
AB  - The aim of our study was to investigate the activities of copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR), as well as ascorbic acid (AsA), vitamin E (Vit E) and lipide peroxide (LP) concentrations in the blood of male two months old Wistar albino rats. The animals were divided as follows: (1) untreated controls (C); (2) animals treated with 14 mg/day/kg b.m. cadmium in drinking water during 15 days (Cd); (3) rats treated with 20 IU/kg/dose of Vit E and 15 mg/kg/dose of coenzyme Q10 (CoQ10), i.m., every fifth day during 15 days (Vit E+CoQ10) and (4) animals pretreated with Vit E and CoQ10 in above mentioned amounts during 15 days and then treated with 14 mg/day/kg b.m. of Cd during next 15 days (Cd+Vit E+CoQ10). Each group consisted of seven animals.               All obtained results were compared in respect to the control animals.
   Cadmium induced a significant increase of GST activity, as well as Vit E concentration in the plasma. In Vit E+CoQ10 treated animals the activities of GSH-Px and GR in erythrocytes were significantly decreased, whereas plasma AsA and Vit E concentrations were markedly elevated.          In Cd+Vit E+CoQ10 treated rats erythrocyte GSH-Px and GR activities, as well as plasma Vit E concentration were significantly increased, while plasma AsA concentration was significantly decreased. In all examined groups of animals LP concentration in the whole blood was significantly decreased. The obtained results show that Cd in the dosages administered influenced antioxidant defense system in the blood of rats and the protective role of Vit E and CoQ10 against Cd toxicity was also observed.
PB  - Society for Free Radical Research - Africa
C3  - Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius
T1  - Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6117
ER  - 

@conference{
author = "Saičić, Zorica and Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the activities of copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR), as well as ascorbic acid (AsA), vitamin E (Vit E) and lipide peroxide (LP) concentrations in the blood of male two months old Wistar albino rats. The animals were divided as follows: (1) untreated controls (C); (2) animals treated with 14 mg/day/kg b.m. cadmium in drinking water during 15 days (Cd); (3) rats treated with 20 IU/kg/dose of Vit E and 15 mg/kg/dose of coenzyme Q10 (CoQ10), i.m., every fifth day during 15 days (Vit E+CoQ10) and (4) animals pretreated with Vit E and CoQ10 in above mentioned amounts during 15 days and then treated with 14 mg/day/kg b.m. of Cd during next 15 days (Cd+Vit E+CoQ10). Each group consisted of seven animals.               All obtained results were compared in respect to the control animals.
   Cadmium induced a significant increase of GST activity, as well as Vit E concentration in the plasma. In Vit E+CoQ10 treated animals the activities of GSH-Px and GR in erythrocytes were significantly decreased, whereas plasma AsA and Vit E concentrations were markedly elevated.          In Cd+Vit E+CoQ10 treated rats erythrocyte GSH-Px and GR activities, as well as plasma Vit E concentration were significantly increased, while plasma AsA concentration was significantly decreased. In all examined groups of animals LP concentration in the whole blood was significantly decreased. The obtained results show that Cd in the dosages administered influenced antioxidant defense system in the blood of rats and the protective role of Vit E and CoQ10 against Cd toxicity was also observed.",
publisher = "Society for Free Radical Research - Africa",
journal = "Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius",
title = "Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6117"
}

Saičić, Z., Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V.,& Petrović, V. M.. (2001). Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium. in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius
Society for Free Radical Research - Africa., 56-56.
https://hdl.handle.net/21.15107/rcub_ibiss_6117

Saičić Z, Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Petrović VM. Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium. in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius. 2001;:56-56.
https://hdl.handle.net/21.15107/rcub_ibiss_6117 .

Saičić, Zorica, Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., "Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium" in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius (2001):56-56,
https://hdl.handle.net/21.15107/rcub_ibiss_6117 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6116
AB  - The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on the  activities  of  superoxide  dismutases: total  (Tot  SOD),  copper  zinc  containing  (CuZn  SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px,) glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control rats (C) and (2) rats treated with 20 mg/kg/dose of coenzyme Q10 by i.m. injections, every fifth day during 30 days  (CoQ10).
An average intake of CoQ10 was 16 mg/kg/dose. All obtained results were compared in respect to the control animals.
The obtained data shows that Tot SOD activity was significantly increased in the heart  of CoQ10 treated animals. At the same time, the activity of CuZn SOD was also increased in the heart, as well as in testes of CoQ10 treated rats. Mn SOD activity was markedly decreased in kidneys and testes, while in heart was significantly increased. The activity of CAT was significantly decreased in liver, kidneys and heart, whereas GSH-Px activity was decreased only in the kidneys of CoQ10 treated animals. At the same time, GSH-Px activity was markedly elevated in heart and testes. Finally, the activity of GR was significantly decreased in the heart of animals received CoQ10.
The obtained results show that CoQ1O in the dosage administered influenced antioxidant enzyme activities in examined tissues of rats. It is also shown that various tissues exhibit different response to CoQ10 depending of their metabolic activity.
PB  - Society for Free Radical Research, European Region
C3  - Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy
T1  - Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10
SP  - PP38
EP  - PP38
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6116
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on the  activities  of  superoxide  dismutases: total  (Tot  SOD),  copper  zinc  containing  (CuZn  SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px,) glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control rats (C) and (2) rats treated with 20 mg/kg/dose of coenzyme Q10 by i.m. injections, every fifth day during 30 days  (CoQ10).
An average intake of CoQ10 was 16 mg/kg/dose. All obtained results were compared in respect to the control animals.
The obtained data shows that Tot SOD activity was significantly increased in the heart  of CoQ10 treated animals. At the same time, the activity of CuZn SOD was also increased in the heart, as well as in testes of CoQ10 treated rats. Mn SOD activity was markedly decreased in kidneys and testes, while in heart was significantly increased. The activity of CAT was significantly decreased in liver, kidneys and heart, whereas GSH-Px activity was decreased only in the kidneys of CoQ10 treated animals. At the same time, GSH-Px activity was markedly elevated in heart and testes. Finally, the activity of GR was significantly decreased in the heart of animals received CoQ10.
The obtained results show that CoQ1O in the dosage administered influenced antioxidant enzyme activities in examined tissues of rats. It is also shown that various tissues exhibit different response to CoQ10 depending of their metabolic activity.",
publisher = "Society for Free Radical Research, European Region",
journal = "Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy",
title = "Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10",
pages = "PP38-PP38",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6116"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10. in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy
Society for Free Radical Research, European Region., PP38-PP38.
https://hdl.handle.net/21.15107/rcub_ibiss_6116

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10. in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy. 2001;:PP38-PP38.
https://hdl.handle.net/21.15107/rcub_ibiss_6116 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10" in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy (2001):PP38-PP38,
https://hdl.handle.net/21.15107/rcub_ibiss_6116 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6115
AB  - We investigated the activity of antioxidant enzymes: superoxide dismutases - total (Tot SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-PX) and glutathione-S-transferase (GST) in the liver, kidneys, heart and interscapular brown adipose tissue (IBAT), as well as contents of ascorbic acid (AsA) and vitamin E (Vit E) in the liver and kidneys of male two months old Wistar albino rats. The animals were divided in two experimental groups: control animals (C) and animals treated with selenium (Se). The rats treated with selenium were drank water _c ontaining 0.1 µg/mL selenium (Se) as Na-selenite during 30 days. The average daily intake of 7 µg Se/kg body mass was calculated from the water consumed. Both experimental groups consisted of seven animals. The obtained results were compared in respect to the control animals. .
Our results show that Tot SOD and CuZn SOD activities were significantly increased in the liver (p<0.02), kidneys (p<0.005), heart (p<0.005) and IBAT (p<0.05) of Se treated animals, while the activity of Mn SOD was significantly increased only in the liver (p<0.02). CAT-activitywas statistically increased in the liver (p<0.02) of animals treated with Se, while the GSH-Px activity was significantly increased only in the heart (p<0.02). The activity of GST was significantly increased in  the liver (p<0.02), kidneys (p<0.02) and heart (p<0.005) of Se treated  animals.
The obtained results show that AsA content in the liver and kidneys was significantly increased (p<0.02 and p<0.05, respectively). The content of Vit E was also significantly increased in the liver (p<0.005) and kidneys (p<0.005) of animals exposed to Se.
Presented results show that oral intake of Se as Na-selenite, improves antioxidant defense system by increasing antioxidant enzyme activities, as well as, by elevation of AsA and Vit E contents in the all examined tissues of rats.
PB  - Institute of Biophysics, Chinese Academy of Sciences
C3  - Programme and Abstracts: The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects; 2001 Jun 4-8; Beijing, China
T1  - Alterations of antioxidant defense system in some tissues of rats treated with selenium
SP  - 169
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6115
ER  - 

@conference{
author = "Ognjanović, Branka and Žikić, Radoslav V. and Štajn, Andraš Š. and Pavlović, Slađan and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "We investigated the activity of antioxidant enzymes: superoxide dismutases - total (Tot SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-PX) and glutathione-S-transferase (GST) in the liver, kidneys, heart and interscapular brown adipose tissue (IBAT), as well as contents of ascorbic acid (AsA) and vitamin E (Vit E) in the liver and kidneys of male two months old Wistar albino rats. The animals were divided in two experimental groups: control animals (C) and animals treated with selenium (Se). The rats treated with selenium were drank water _c ontaining 0.1 µg/mL selenium (Se) as Na-selenite during 30 days. The average daily intake of 7 µg Se/kg body mass was calculated from the water consumed. Both experimental groups consisted of seven animals. The obtained results were compared in respect to the control animals. .
Our results show that Tot SOD and CuZn SOD activities were significantly increased in the liver (p<0.02), kidneys (p<0.005), heart (p<0.005) and IBAT (p<0.05) of Se treated animals, while the activity of Mn SOD was significantly increased only in the liver (p<0.02). CAT-activitywas statistically increased in the liver (p<0.02) of animals treated with Se, while the GSH-Px activity was significantly increased only in the heart (p<0.02). The activity of GST was significantly increased in  the liver (p<0.02), kidneys (p<0.02) and heart (p<0.005) of Se treated  animals.
The obtained results show that AsA content in the liver and kidneys was significantly increased (p<0.02 and p<0.05, respectively). The content of Vit E was also significantly increased in the liver (p<0.005) and kidneys (p<0.005) of animals exposed to Se.
Presented results show that oral intake of Se as Na-selenite, improves antioxidant defense system by increasing antioxidant enzyme activities, as well as, by elevation of AsA and Vit E contents in the all examined tissues of rats.",
publisher = "Institute of Biophysics, Chinese Academy of Sciences",
journal = "Programme and Abstracts: The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects; 2001 Jun 4-8; Beijing, China",
title = "Alterations of antioxidant defense system in some tissues of rats treated with selenium",
pages = "169-169",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6115"
}

Ognjanović, B., Žikić, R. V., Štajn, A. Š., Pavlović, S., Saičić, Z.,& Petrović, V. M.. (2001). Alterations of antioxidant defense system in some tissues of rats treated with selenium. in Programme and Abstracts: The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects; 2001 Jun 4-8; Beijing, China
Institute of Biophysics, Chinese Academy of Sciences., 169-169.
https://hdl.handle.net/21.15107/rcub_ibiss_6115

Ognjanović B, Žikić RV, Štajn AŠ, Pavlović S, Saičić Z, Petrović VM. Alterations of antioxidant defense system in some tissues of rats treated with selenium. in Programme and Abstracts: The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects; 2001 Jun 4-8; Beijing, China. 2001;:169-169.
https://hdl.handle.net/21.15107/rcub_ibiss_6115 .

Ognjanović, Branka, Žikić, Radoslav V., Štajn, Andraš Š., Pavlović, Slađan, Saičić, Zorica, Petrović, Vojislav M., "Alterations of antioxidant defense system in some tissues of rats treated with selenium" in Programme and Abstracts: The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects; 2001 Jun 4-8; Beijing, China (2001):169-169,
https://hdl.handle.net/21.15107/rcub_ibiss_6115 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5968
AB  - In our experiments male 2-month-old Wistar albino rats were divided as follows: (i) untreated controls (C); (ii) animals treated with 14 mg/day/kg· b.m. cadmium in drinking water during 15 days (Cd); (iii) rats treated with 20 I/kg/dose of Vitamin E (Vit E) and 15 m/kg/dose of coenzyme Q10 (CoQ10) i.m., every fifth day during 15 days (Vit E + CoQIO) and (iv) animals pretreated with Vit E and CoQ10 in
above mentioned amounts during 15 days, and then treated with 14 m/day/kg b.m. of Cd during next 15 days (Cd + Vit E + CoQ10). We measured the following parameters of energy metabolism: glucose (Gly), lactate (Lac) and pyruvate (Pyr) levels , Lac/Pyr ratio, ATP, ADP and AMP levels, ATP/ADP ratio, total adenine nucleotide (TAN) levels and adenylate energy charge (AEC). All obtained results were compared in respect to the control animals. Our results show that Gly level did not changed, while Lac and Pyr levels were significantly increased in Vit E + CoQ10 treated rats. At the same time Lac/Pyr ratio was significantly decreased. In Cd and Cd + Vit E + CoQ10 treated animals ATP level was significantly decreased, whereas AMP level was significantly increased. ADP  level  did  not  significantly  alter  in  any  of  examined  group  of  animals. A significant decrease of ATP/ADP ratio and TAN levels in the same experimental groups were observed. AEC did not alter in any of investigated group of rats. It can be concluded that Vit E and CoQ IO have partial protect i, ·e role on energy metabolism in the blood of rats influenced by Cd.
PB  - Bleckwell Science
C3  - 27th Meeting of the Federation of European Biochemical Societies; 2001 Jun 30 - Jul 5; Lisbon, Portugal
T1  - The influence of cadmium on energy metabolism in the blood of rats. A possible protective role of vitamin E and coenzyme Q10
SP  - 238
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5968
ER  - 

@conference{
author = "Pavlović, Slađan and Maletić, Snežana and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "In our experiments male 2-month-old Wistar albino rats were divided as follows: (i) untreated controls (C); (ii) animals treated with 14 mg/day/kg· b.m. cadmium in drinking water during 15 days (Cd); (iii) rats treated with 20 I/kg/dose of Vitamin E (Vit E) and 15 m/kg/dose of coenzyme Q10 (CoQ10) i.m., every fifth day during 15 days (Vit E + CoQIO) and (iv) animals pretreated with Vit E and CoQ10 in
above mentioned amounts during 15 days, and then treated with 14 m/day/kg b.m. of Cd during next 15 days (Cd + Vit E + CoQ10). We measured the following parameters of energy metabolism: glucose (Gly), lactate (Lac) and pyruvate (Pyr) levels , Lac/Pyr ratio, ATP, ADP and AMP levels, ATP/ADP ratio, total adenine nucleotide (TAN) levels and adenylate energy charge (AEC). All obtained results were compared in respect to the control animals. Our results show that Gly level did not changed, while Lac and Pyr levels were significantly increased in Vit E + CoQ10 treated rats. At the same time Lac/Pyr ratio was significantly decreased. In Cd and Cd + Vit E + CoQ10 treated animals ATP level was significantly decreased, whereas AMP level was significantly increased. ADP  level  did  not  significantly  alter  in  any  of  examined  group  of  animals. A significant decrease of ATP/ADP ratio and TAN levels in the same experimental groups were observed. AEC did not alter in any of investigated group of rats. It can be concluded that Vit E and CoQ IO have partial protect i, ·e role on energy metabolism in the blood of rats influenced by Cd.",
publisher = "Bleckwell Science",
journal = "27th Meeting of the Federation of European Biochemical Societies; 2001 Jun 30 - Jul 5; Lisbon, Portugal",
title = "The influence of cadmium on energy metabolism in the blood of rats. A possible protective role of vitamin E and coenzyme Q10",
pages = "238",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5968"
}

Pavlović, S., Maletić, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). The influence of cadmium on energy metabolism in the blood of rats. A possible protective role of vitamin E and coenzyme Q10. in 27th Meeting of the Federation of European Biochemical Societies; 2001 Jun 30 - Jul 5; Lisbon, Portugal
Bleckwell Science., 238.
https://hdl.handle.net/21.15107/rcub_ibiss_5968

Pavlović S, Maletić S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The influence of cadmium on energy metabolism in the blood of rats. A possible protective role of vitamin E and coenzyme Q10. in 27th Meeting of the Federation of European Biochemical Societies; 2001 Jun 30 - Jul 5; Lisbon, Portugal. 2001;:238.
https://hdl.handle.net/21.15107/rcub_ibiss_5968 .

Pavlović, Slađan, Maletić, Snežana, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The influence of cadmium on energy metabolism in the blood of rats. A possible protective role of vitamin E and coenzyme Q10" in 27th Meeting of the Federation of European Biochemical Societies; 2001 Jun 30 - Jul 5; Lisbon, Portugal (2001):238,
https://hdl.handle.net/21.15107/rcub_ibiss_5968 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6114
AB  - The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on antioxidant enzyme activities in the blood of male, two months old Wistar albino rats. We measured the activities of copper zinc contaiuing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBCs), as well as glutathione-S-transferase activity in the plasma.
The an mals were divided in two experimental groups: (1) control rats (C) and (2) rats  treated  with  20  mg/kg/dose ofcoenzyme Q10 by i.m. injections, every fifth day during 30 days (CoQ10) . An average intake of  CoQ10 was 16 mg/kg/dose. After the trearm ent, the animals were  exanguinated  by  decapitation  alw ays between  8 and  IO A.M. and fresh blood  was collected  in heparinized  test  tubes.
The obtained results show that CoQ10 did not influenced the activities of CuZn SOD and CAT in RBCs of rats. By quenching organic oxygen-derived free radicals CoQ10 protects GSH-Px and activity of this enzyme molecule in RBCs of rats treated with CoQ10 was significantly decreased  in comparison  to the control animals (p<0.05). After the treatment of rats with CoQ10 the activity of GST in the plasma was significantly elevated in respect to the controls (p<0.02).
Our findings confirm the results of earlier investigations, which were also showed that CoQ10 causes an increased activity of GST, and thus improve defense from oxidant injuries in normal and pathophysiological conditions.
PB  - Bucharest: Romanian Society for Biochemistry and molecular Biology
C3  - Book of abstracts: 12th BBBD Balkan Biochemical and Biophysical days: Molecular sciences in post-genomic era; 2001 May 10-13; Bucharest, Romania
T1  - Antioxidant enzyme activities in the blood of rats treated with coenzyme Q10
SP  - 105
EP  - 105
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6114
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on antioxidant enzyme activities in the blood of male, two months old Wistar albino rats. We measured the activities of copper zinc contaiuing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBCs), as well as glutathione-S-transferase activity in the plasma.
The an mals were divided in two experimental groups: (1) control rats (C) and (2) rats  treated  with  20  mg/kg/dose ofcoenzyme Q10 by i.m. injections, every fifth day during 30 days (CoQ10) . An average intake of  CoQ10 was 16 mg/kg/dose. After the trearm ent, the animals were  exanguinated  by  decapitation  alw ays between  8 and  IO A.M. and fresh blood  was collected  in heparinized  test  tubes.
The obtained results show that CoQ10 did not influenced the activities of CuZn SOD and CAT in RBCs of rats. By quenching organic oxygen-derived free radicals CoQ10 protects GSH-Px and activity of this enzyme molecule in RBCs of rats treated with CoQ10 was significantly decreased  in comparison  to the control animals (p<0.05). After the treatment of rats with CoQ10 the activity of GST in the plasma was significantly elevated in respect to the controls (p<0.02).
Our findings confirm the results of earlier investigations, which were also showed that CoQ10 causes an increased activity of GST, and thus improve defense from oxidant injuries in normal and pathophysiological conditions.",
publisher = "Bucharest: Romanian Society for Biochemistry and molecular Biology",
journal = "Book of abstracts: 12th BBBD Balkan Biochemical and Biophysical days: Molecular sciences in post-genomic era; 2001 May 10-13; Bucharest, Romania",
title = "Antioxidant enzyme activities in the blood of rats treated with coenzyme Q10",
pages = "105-105",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6114"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). Antioxidant enzyme activities in the blood of rats treated with coenzyme Q10. in Book of abstracts: 12th BBBD Balkan Biochemical and Biophysical days: Molecular sciences in post-genomic era; 2001 May 10-13; Bucharest, Romania
Bucharest: Romanian Society for Biochemistry and molecular Biology., 105-105.
https://hdl.handle.net/21.15107/rcub_ibiss_6114

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. Antioxidant enzyme activities in the blood of rats treated with coenzyme Q10. in Book of abstracts: 12th BBBD Balkan Biochemical and Biophysical days: Molecular sciences in post-genomic era; 2001 May 10-13; Bucharest, Romania. 2001;:105-105.
https://hdl.handle.net/21.15107/rcub_ibiss_6114 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "Antioxidant enzyme activities in the blood of rats treated with coenzyme Q10" in Book of abstracts: 12th BBBD Balkan Biochemical and Biophysical days: Molecular sciences in post-genomic era; 2001 May 10-13; Bucharest, Romania (2001):105-105,
https://hdl.handle.net/21.15107/rcub_ibiss_6114 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6019
AB  - The purpose of our study was to elucidate the effects of olive oil on antioxidant enzyme activities: superoxide dismutases (SODs): total (Tot SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male, two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control animals {C) and (2) animals treated with olive oil (o. oil, 100 mL of virgin olive oil, i.m., every fifth day during 30 days). All animals were decapitated at the end of treatment always between 8 and 10 a.m. to avoid any possible rhythmic variations in the antioxidant level. Both experimental groups consisted of seven rats. The obtained results were compared in'respectto the control animals.

Our results show that olive oil induced a significant decrease of Tot SOD activity in liver, kidneys and heart of rats, while in testes Tot SOD activity was significantly increased. At the same time, CuZn SOD activity was significantly increased in kidneys and heart, whereas in testes was significantly decreased. Contrary, Mn SOD activity was significantly decreased in kidneys, heart and testes of animals treated with olive oil. The activity of CAT was markedly decreased in liver, kidneys and heart of animals treated with olive oil, while in testes CAT activity was significantly increased. GSH-Px activity was significantly decreased in liver, kidneys and heart, whereas in testes the changes was not observed. The activity of GR was significantly increased only in the liver of animals treated with olive oil.

The obtained results show that olive oil influenced antioxidant enzyme activities in all examined tissues of rats. At the same time various tissues exhibit different response to olive oil, depending of their metabolic activity.
PB  - Kuopio: Kuopion Yliopisto
C3  - Abstracts: Third International Conference on	Natural Antioxidants and Anticarcinogens In Food, Health and Disease: NAHD 2001; 2001 Jun 6-9; Helsinki, Finland
T1  - The effects of olive oil on antioxidant enzyme activities in some tissues of rats
DO  - 978-951-781-846-7
SP  - 87
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The purpose of our study was to elucidate the effects of olive oil on antioxidant enzyme activities: superoxide dismutases (SODs): total (Tot SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male, two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control animals {C) and (2) animals treated with olive oil (o. oil, 100 mL of virgin olive oil, i.m., every fifth day during 30 days). All animals were decapitated at the end of treatment always between 8 and 10 a.m. to avoid any possible rhythmic variations in the antioxidant level. Both experimental groups consisted of seven rats. The obtained results were compared in'respectto the control animals.

Our results show that olive oil induced a significant decrease of Tot SOD activity in liver, kidneys and heart of rats, while in testes Tot SOD activity was significantly increased. At the same time, CuZn SOD activity was significantly increased in kidneys and heart, whereas in testes was significantly decreased. Contrary, Mn SOD activity was significantly decreased in kidneys, heart and testes of animals treated with olive oil. The activity of CAT was markedly decreased in liver, kidneys and heart of animals treated with olive oil, while in testes CAT activity was significantly increased. GSH-Px activity was significantly decreased in liver, kidneys and heart, whereas in testes the changes was not observed. The activity of GR was significantly increased only in the liver of animals treated with olive oil.

The obtained results show that olive oil influenced antioxidant enzyme activities in all examined tissues of rats. At the same time various tissues exhibit different response to olive oil, depending of their metabolic activity.",
publisher = "Kuopio: Kuopion Yliopisto",
journal = "Abstracts: Third International Conference on	Natural Antioxidants and Anticarcinogens In Food, Health and Disease: NAHD 2001; 2001 Jun 6-9; Helsinki, Finland",
title = "The effects of olive oil on antioxidant enzyme activities in some tissues of rats",
doi = "978-951-781-846-7",
pages = "87"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). The effects of olive oil on antioxidant enzyme activities in some tissues of rats. in Abstracts: Third International Conference on	Natural Antioxidants and Anticarcinogens In Food, Health and Disease: NAHD 2001; 2001 Jun 6-9; Helsinki, Finland
Kuopio: Kuopion Yliopisto., 87.
https://doi.org/978-951-781-846-7

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The effects of olive oil on antioxidant enzyme activities in some tissues of rats. in Abstracts: Third International Conference on	Natural Antioxidants and Anticarcinogens In Food, Health and Disease: NAHD 2001; 2001 Jun 6-9; Helsinki, Finland. 2001;:87.
doi:978-951-781-846-7 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The effects of olive oil on antioxidant enzyme activities in some tissues of rats" in Abstracts: Third International Conference on	Natural Antioxidants and Anticarcinogens In Food, Health and Disease: NAHD 2001; 2001 Jun 6-9; Helsinki, Finland (2001):87,
https://doi.org/978-951-781-846-7 . .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Žikić, Andraš Š.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5915
AB  - Globalni problem savremenog sveta je proizvodnja dovoljnih količina visokokvalitetne i zdrave hrane. Savremene studije pokazuju da je jedan od najvažnijih faktora koji utiču na kvalitet hrane održavanje njene oksidacione stabilnosti. Istraživanja oksidacione stabilnosti hrane nameću potrebu uvođenja novih kriterijuma i standarda koji bi obuhvatili i određivanje antioksidacionih komponenata u hrani. Rezultati naših istraživanja pokazuju da tretman koenzimom Q10, vitaminom E i maslinovim uljem, povećava antioksidacioni status (enzimske i neenzimske komponente) u tkivima pacova.
PB  - Donji Milanovac: Organizacioni odbor "Ekološke istine 2001"
C3  - Zbornik radova: IX naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XIV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2001 Jun 6
T1  - Biološki značaj antioksidanata - važan faktor visoko kvalitetne hrane
SP  - 359
EP  - 364
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5915
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Žikić, Andraš Š. and Štajn, Andraš Š. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "Globalni problem savremenog sveta je proizvodnja dovoljnih količina visokokvalitetne i zdrave hrane. Savremene studije pokazuju da je jedan od najvažnijih faktora koji utiču na kvalitet hrane održavanje njene oksidacione stabilnosti. Istraživanja oksidacione stabilnosti hrane nameću potrebu uvođenja novih kriterijuma i standarda koji bi obuhvatili i određivanje antioksidacionih komponenata u hrani. Rezultati naših istraživanja pokazuju da tretman koenzimom Q10, vitaminom E i maslinovim uljem, povećava antioksidacioni status (enzimske i neenzimske komponente) u tkivima pacova.",
publisher = "Donji Milanovac: Organizacioni odbor "Ekološke istine 2001"",
journal = "Zbornik radova: IX naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XIV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2001 Jun 6",
title = "Biološki značaj antioksidanata - važan faktor visoko kvalitetne hrane",
pages = "359-364",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5915"
}

Ognjanović, B., Pavlović, S., Žikić, A. Š., Štajn, A. Š., Saičić, Z.,& Petrović, V. M.. (2001). Biološki značaj antioksidanata - važan faktor visoko kvalitetne hrane. in Zbornik radova: IX naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XIV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2001 Jun 6
Donji Milanovac: Organizacioni odbor "Ekološke istine 2001"., 359-364.
https://hdl.handle.net/21.15107/rcub_ibiss_5915

Ognjanović B, Pavlović S, Žikić AŠ, Štajn AŠ, Saičić Z, Petrović VM. Biološki značaj antioksidanata - važan faktor visoko kvalitetne hrane. in Zbornik radova: IX naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XIV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2001 Jun 6. 2001;:359-364.
https://hdl.handle.net/21.15107/rcub_ibiss_5915 .

Ognjanović, Branka, Pavlović, Slađan, Žikić, Andraš Š., Štajn, Andraš Š., Saičić, Zorica, Petrović, Vojislav M., "Biološki značaj antioksidanata - važan faktor visoko kvalitetne hrane" in Zbornik radova: IX naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XIV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2001 Jun 6 (2001):359-364,
https://hdl.handle.net/21.15107/rcub_ibiss_5915 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5914
AB  - The aim of our study was to investigate the possible protective role of coenizyme Q10 administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blopd of rats chronically treated with cadmium. Results were compared to dtase obtained in control animals, as well as to those obtained in animals treated with olive pil. Compared to that of the control animals, the AsA concentration was aignificantiy Smeared in rats treated with Como olive oil, whereas vit E concentration cas significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. A significant decrease in LP concentraiion was noted in arrivals treated with cadmium or with cadmium + CoO10, whereas a aig;iificant increase was seen in animals treated with olive oil. Compared to that of the animals treated uith olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ10, whereas vit k concentration was significantly increased in an 
61 Cdflt)y decreased in rats treated with cadmium, CoQ10 , or cadmium + CoQ10. Our study showed that CoQ10 administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting inâ decreased concentration of LP in the blood.
PB  - Begell House, Inc.
T2  - Journal of Environmental Pathology, Toxicology and Oncology
T1  - The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication
IS  - 2
VL  - 20
DO  - 10.1615/JEnvironPatholToxicolOncol.v20.i2.80
SP  - 133
EP  - 140
ER  - 

@article{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the possible protective role of coenizyme Q10 administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blopd of rats chronically treated with cadmium. Results were compared to dtase obtained in control animals, as well as to those obtained in animals treated with olive pil. Compared to that of the control animals, the AsA concentration was aignificantiy Smeared in rats treated with Como olive oil, whereas vit E concentration cas significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. A significant decrease in LP concentraiion was noted in arrivals treated with cadmium or with cadmium + CoO10, whereas a aig;iificant increase was seen in animals treated with olive oil. Compared to that of the animals treated uith olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ10, whereas vit k concentration was significantly increased in an 
61 Cdflt)y decreased in rats treated with cadmium, CoQ10 , or cadmium + CoQ10. Our study showed that CoQ10 administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting inâ decreased concentration of LP in the blood.",
publisher = "Begell House, Inc.",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
title = "The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication",
number = "2",
volume = "20",
doi = "10.1615/JEnvironPatholToxicolOncol.v20.i2.80",
pages = "133-140"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication. in Journal of Environmental Pathology, Toxicology and Oncology
Begell House, Inc.., 20(2), 133-140.
https://doi.org/10.1615/JEnvironPatholToxicolOncol.v20.i2.80

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication. in Journal of Environmental Pathology, Toxicology and Oncology. 2001;20(2):133-140.
doi:10.1615/JEnvironPatholToxicolOncol.v20.i2.80 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication" in Journal of Environmental Pathology, Toxicology and Oncology, 20, no. 2 (2001):133-140,
https://doi.org/10.1615/JEnvironPatholToxicolOncol.v20.i2.80 . .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6029
AB  - We determined the activities of antioxidant enzymes: superoxide dismutases - total  (tot. SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase  (GSH- Px),  glutathione--S-transferase  (GST)  and  glutathione  reductase (GR) in male, two months old vVistar albino rats. The animals were treated with cadmium (17 mg/day/kg  b.m. in drinking  water), Coenzyme  Q10   (C0Q10 , I6  mg/kg,  i.m.,  every  fifth  day)  and Cd+CoQ10 (17 mg/day/kg b.m. Cd in drin."l(ing water + 16 mg/kg, CoQ10 , i.m., every  fifth  day ) during 30 days. The activities of tot. SOD and CuZn  SOD  were  significantly  increased  in  Cd treated animals, while the activity of manganese containing superoxide dismutase (Mn SOD) was significantly decreased. In animals treated with CoQ10 Mn SOD was significantly decreas ct. The activity of CAT was  significantly  decreased  in  animals  treated  with  CoQ10 and  Cd+CoQ1c, whereas GSH-Px activity was  significantly  decreased  in  rats  treated  with  Cd,  CoQ1 0  and Cd+CoQ10 • GST activity was significantly decreased in rats exposed to Cd, CoQ10 and Cd+CoQ10 . No significant changes of GR activity  in any of investigated  experimental  groups were observed. Our results show that CoQ10 exibit protective effects on the activities of  antioxidant  enzymes  in kidneys of rats chronically  exposed  to  cadmium.
PB  - Society fro free radical research (SFRR)
C3  - 10th Biennial Meeting of the International Society for Free Radical Research (SFRR 200): Free radicals in disease and aging research for the new millennium; 2000 Oct 16-20; Kyoto, Japan
T1  - The effects of cadmium and coenzyme Q10 on the activity of antioxidant enzymes in kidneys of rats
SP  - 42
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6029
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "We determined the activities of antioxidant enzymes: superoxide dismutases - total  (tot. SOD), copper zinc containing (CuZn SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase  (GSH- Px),  glutathione--S-transferase  (GST)  and  glutathione  reductase (GR) in male, two months old vVistar albino rats. The animals were treated with cadmium (17 mg/day/kg  b.m. in drinking  water), Coenzyme  Q10   (C0Q10 , I6  mg/kg,  i.m.,  every  fifth  day)  and Cd+CoQ10 (17 mg/day/kg b.m. Cd in drin."l(ing water + 16 mg/kg, CoQ10 , i.m., every  fifth  day ) during 30 days. The activities of tot. SOD and CuZn  SOD  were  significantly  increased  in  Cd treated animals, while the activity of manganese containing superoxide dismutase (Mn SOD) was significantly decreased. In animals treated with CoQ10 Mn SOD was significantly decreas ct. The activity of CAT was  significantly  decreased  in  animals  treated  with  CoQ10 and  Cd+CoQ1c, whereas GSH-Px activity was  significantly  decreased  in  rats  treated  with  Cd,  CoQ1 0  and Cd+CoQ10 • GST activity was significantly decreased in rats exposed to Cd, CoQ10 and Cd+CoQ10 . No significant changes of GR activity  in any of investigated  experimental  groups were observed. Our results show that CoQ10 exibit protective effects on the activities of  antioxidant  enzymes  in kidneys of rats chronically  exposed  to  cadmium.",
publisher = "Society fro free radical research (SFRR)",
journal = "10th Biennial Meeting of the International Society for Free Radical Research (SFRR 200): Free radicals in disease and aging research for the new millennium; 2000 Oct 16-20; Kyoto, Japan",
title = "The effects of cadmium and coenzyme Q10 on the activity of antioxidant enzymes in kidneys of rats",
pages = "42-42",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6029"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2000). The effects of cadmium and coenzyme Q10 on the activity of antioxidant enzymes in kidneys of rats. in 10th Biennial Meeting of the International Society for Free Radical Research (SFRR 200): Free radicals in disease and aging research for the new millennium; 2000 Oct 16-20; Kyoto, Japan
Society fro free radical research (SFRR)., 42-42.
https://hdl.handle.net/21.15107/rcub_ibiss_6029

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The effects of cadmium and coenzyme Q10 on the activity of antioxidant enzymes in kidneys of rats. in 10th Biennial Meeting of the International Society for Free Radical Research (SFRR 200): Free radicals in disease and aging research for the new millennium; 2000 Oct 16-20; Kyoto, Japan. 2000;:42-42.
https://hdl.handle.net/21.15107/rcub_ibiss_6029 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The effects of cadmium and coenzyme Q10 on the activity of antioxidant enzymes in kidneys of rats" in 10th Biennial Meeting of the International Society for Free Radical Research (SFRR 200): Free radicals in disease and aging research for the new millennium; 2000 Oct 16-20; Kyoto, Japan (2000):42-42,
https://hdl.handle.net/21.15107/rcub_ibiss_6029 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6031
AB  - The aim of our study was to investigate the activities of total superoxide dismutase (Total SOD), manganese containing superoxide dismutase (Mn SOD), copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), glutathione reductase (GR) as well as ascorbic acid (AsA) and vitamin E (Vit E) concentrations in the heart of male, two months old Wistar albino rats. The animals were divided in four experimental groups: (1) controls (C), (2) treated with cadmium (Cd, 200 mg CdCl2 x H2O, in drinking water during 30 days), (3) treated with coenzyme Q10 (CoQ10, 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and (4) concomitantly treated with cadmium and coenzyme Q10 (Cd+CoQ10, 200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day). An average intake of           17 mg Cd/day/kg body mass was calculated from the water consumed and an average intake of CoQ10 was 16 mg/kg/dose. Each experimental group consisted of seven animals. After the treatment the rats were sacrificed by decapitation and heart tissue was isolated and prepared for analysis.
	The obtained results show that Cd in the heart induces a significant increase of Total SOD, CuZn SOD and GSH-Px activities as well as AsA and Vit E concentrations in comparison to the control rats. At the same time, treatment with Cd leads to a significant decrease of CAT and GR activities. In the heart of rats treated with CoQ10 a significant increase of Total SOD, Mn SOD, CuZn SOD and GSH-Px activities as well as AsA and Vit E concentrations were observed. In the same group of animals, the activities of CAT, GST and GR were significantly decreased in respect to the control rats. By concomitant treatment of rats with Cd+CoQ10 the activities of Total SOD and Mn SOD were markedly increased in relation to the controls, while CuZn SOD activity was significantly decreased. In the animals concomitantly treated with Cd+CoQ10 the activities of CAT and GR were significantly decreased, whereas     GSH-Px activity and AsA and Vit E concentrations were significantly increased in relation to the control rats.
	From the presented results, it may be concluded that Cd and CoQ10 in the dosages administered influenced antioxidant defence system (AOS) in the heart of rats. The protective role of CoQ10 on AOS in the heart of rats against Cd toxicity was also observed.
PB  - Society of free radical research, Europe
C3  - Abstract Book: 2nd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology: Winter Meeting of Society of Free radical Research - Europe; 2000 Nov 30 - Dec 2; Valencia, Spain
T1  - Changes of antioxidant defence system in the heart of rats treated with cadmium and coenzyme Q10
SP  - 81
EP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6031
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "The aim of our study was to investigate the activities of total superoxide dismutase (Total SOD), manganese containing superoxide dismutase (Mn SOD), copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), glutathione reductase (GR) as well as ascorbic acid (AsA) and vitamin E (Vit E) concentrations in the heart of male, two months old Wistar albino rats. The animals were divided in four experimental groups: (1) controls (C), (2) treated with cadmium (Cd, 200 mg CdCl2 x H2O, in drinking water during 30 days), (3) treated with coenzyme Q10 (CoQ10, 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and (4) concomitantly treated with cadmium and coenzyme Q10 (Cd+CoQ10, 200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day). An average intake of           17 mg Cd/day/kg body mass was calculated from the water consumed and an average intake of CoQ10 was 16 mg/kg/dose. Each experimental group consisted of seven animals. After the treatment the rats were sacrificed by decapitation and heart tissue was isolated and prepared for analysis.
	The obtained results show that Cd in the heart induces a significant increase of Total SOD, CuZn SOD and GSH-Px activities as well as AsA and Vit E concentrations in comparison to the control rats. At the same time, treatment with Cd leads to a significant decrease of CAT and GR activities. In the heart of rats treated with CoQ10 a significant increase of Total SOD, Mn SOD, CuZn SOD and GSH-Px activities as well as AsA and Vit E concentrations were observed. In the same group of animals, the activities of CAT, GST and GR were significantly decreased in respect to the control rats. By concomitant treatment of rats with Cd+CoQ10 the activities of Total SOD and Mn SOD were markedly increased in relation to the controls, while CuZn SOD activity was significantly decreased. In the animals concomitantly treated with Cd+CoQ10 the activities of CAT and GR were significantly decreased, whereas     GSH-Px activity and AsA and Vit E concentrations were significantly increased in relation to the control rats.
	From the presented results, it may be concluded that Cd and CoQ10 in the dosages administered influenced antioxidant defence system (AOS) in the heart of rats. The protective role of CoQ10 on AOS in the heart of rats against Cd toxicity was also observed.",
publisher = "Society of free radical research, Europe",
journal = "Abstract Book: 2nd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology: Winter Meeting of Society of Free radical Research - Europe; 2000 Nov 30 - Dec 2; Valencia, Spain",
title = "Changes of antioxidant defence system in the heart of rats treated with cadmium and coenzyme Q10",
pages = "81-81",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6031"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2000). Changes of antioxidant defence system in the heart of rats treated with cadmium and coenzyme Q10. in Abstract Book: 2nd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology: Winter Meeting of Society of Free radical Research - Europe; 2000 Nov 30 - Dec 2; Valencia, Spain
Society of free radical research, Europe., 81-81.
https://hdl.handle.net/21.15107/rcub_ibiss_6031

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. Changes of antioxidant defence system in the heart of rats treated with cadmium and coenzyme Q10. in Abstract Book: 2nd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology: Winter Meeting of Society of Free radical Research - Europe; 2000 Nov 30 - Dec 2; Valencia, Spain. 2000;:81-81.
https://hdl.handle.net/21.15107/rcub_ibiss_6031 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "Changes of antioxidant defence system in the heart of rats treated with cadmium and coenzyme Q10" in Abstract Book: 2nd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology: Winter Meeting of Society of Free radical Research - Europe; 2000 Nov 30 - Dec 2; Valencia, Spain (2000):81-81,
https://hdl.handle.net/21.15107/rcub_ibiss_6031 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6030
AB  - The effects of chronic exposure to cadmium (Cd) on the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities and the protective role of coenzyme Q10 (CoQ10) in red blood cells (RBC) of two months old male Wistar albino rats were examined. The animals were exposed to Cd (200 mg CdCl2 x H2O, in drinking water and 100 μL olive oil, i.m., every fifth day), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), Cd+ CoQ10 (200 mg CdCl2 x H2O, in drinking water + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and olive oil (100 μL olive oil, i.m., every fifth day) in course of 30 days. The average intake of Cd was 17 mg/day/kg body mass and CoQ10 16 mg/kg/dose. After the treatment the animals were sacrificed without the anesthaesia and blood was collected and prepared for enzyme analysis. 
	The activity of SOD was significantly decreased in animals treated with olive oil when compared to the controls. At the other hand, in comparison to the animals treated with olive oil, the SOD activity was significantly increased in rats treated with Cd, CoQ10, and Cd+CoQ10. CAT activity was significantly decreased in rats exposed to Cd+CoQ10 and olive oil in respect to the control animals, while in comparison to the animals treated with olive oil CAT activity was significantly increased in animals treated with Cd, CoQ10 and Cd+CoQ10. In comparison to the controls the GSH-Px activity was significantly decreased in RBC of rats exposed to CoQ10 and olive oil. In respect to the animals treated with olive oil, the activity of GSH-Px was increased in animals treated with Cd, CoQ10 and Cd+CoQ10.
	Our results show that cadmium administered with olive oil did not exhibit toxic effects on SOD, CAT and GSH-Px activities in RBC of rats. At the same time, CoQ10 by quenching of free oxygen radicals and by inhibition of lipid peroxidation may improve the antioxidant defense enzyme activities in RBC of rats. Our investigations also show that olive oil exhibit some protective effects on SOD, CAT and GSH-Px activities in red blood cells of rats.
PB  - Łódź: Polish Biophysical Society, Łódź Branch
C3  - Abstracts: 5th Symposium Free Radicals in Biology and Medicine; 2000 Jun 7-10; Łódź, Poland
T1  - The effects of cadmium and coenzyme Q10 on superoxide dismutase, catalase and glutathione peroxidase activities in red blood cells of rats
SP  - 206
EP  - 206
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6030
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "The effects of chronic exposure to cadmium (Cd) on the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities and the protective role of coenzyme Q10 (CoQ10) in red blood cells (RBC) of two months old male Wistar albino rats were examined. The animals were exposed to Cd (200 mg CdCl2 x H2O, in drinking water and 100 μL olive oil, i.m., every fifth day), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), Cd+ CoQ10 (200 mg CdCl2 x H2O, in drinking water + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and olive oil (100 μL olive oil, i.m., every fifth day) in course of 30 days. The average intake of Cd was 17 mg/day/kg body mass and CoQ10 16 mg/kg/dose. After the treatment the animals were sacrificed without the anesthaesia and blood was collected and prepared for enzyme analysis. 
	The activity of SOD was significantly decreased in animals treated with olive oil when compared to the controls. At the other hand, in comparison to the animals treated with olive oil, the SOD activity was significantly increased in rats treated with Cd, CoQ10, and Cd+CoQ10. CAT activity was significantly decreased in rats exposed to Cd+CoQ10 and olive oil in respect to the control animals, while in comparison to the animals treated with olive oil CAT activity was significantly increased in animals treated with Cd, CoQ10 and Cd+CoQ10. In comparison to the controls the GSH-Px activity was significantly decreased in RBC of rats exposed to CoQ10 and olive oil. In respect to the animals treated with olive oil, the activity of GSH-Px was increased in animals treated with Cd, CoQ10 and Cd+CoQ10.
	Our results show that cadmium administered with olive oil did not exhibit toxic effects on SOD, CAT and GSH-Px activities in RBC of rats. At the same time, CoQ10 by quenching of free oxygen radicals and by inhibition of lipid peroxidation may improve the antioxidant defense enzyme activities in RBC of rats. Our investigations also show that olive oil exhibit some protective effects on SOD, CAT and GSH-Px activities in red blood cells of rats.",
publisher = "Łódź: Polish Biophysical Society, Łódź Branch",
journal = "Abstracts: 5th Symposium Free Radicals in Biology and Medicine; 2000 Jun 7-10; Łódź, Poland",
title = "The effects of cadmium and coenzyme Q10 on superoxide dismutase, catalase and glutathione peroxidase activities in red blood cells of rats",
pages = "206-206",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6030"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2000). The effects of cadmium and coenzyme Q10 on superoxide dismutase, catalase and glutathione peroxidase activities in red blood cells of rats. in Abstracts: 5th Symposium Free Radicals in Biology and Medicine; 2000 Jun 7-10; Łódź, Poland
Łódź: Polish Biophysical Society, Łódź Branch., 206-206.
https://hdl.handle.net/21.15107/rcub_ibiss_6030

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The effects of cadmium and coenzyme Q10 on superoxide dismutase, catalase and glutathione peroxidase activities in red blood cells of rats. in Abstracts: 5th Symposium Free Radicals in Biology and Medicine; 2000 Jun 7-10; Łódź, Poland. 2000;:206-206.
https://hdl.handle.net/21.15107/rcub_ibiss_6030 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The effects of cadmium and coenzyme Q10 on superoxide dismutase, catalase and glutathione peroxidase activities in red blood cells of rats" in Abstracts: 5th Symposium Free Radicals in Biology and Medicine; 2000 Jun 7-10; Łódź, Poland (2000):206-206,
https://hdl.handle.net/21.15107/rcub_ibiss_6030 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5935
AB  - Coenzyme  Q10 in  its reduced  form  (CoQ10Hz) is a  powerful  antioxidant.  As  an ant io x idant it is exploited either directly upon superoxide or indirectly on lipid radic als. CoQ:0H2 can also act  together  with  Vitamin  E by regenerating  the
active  form   from  the  tocopheroxyl  radical.  CoQ10  may  prevent  both  the initiation and propagation of lipid peroxidation , prote cts DNA from oxidation
causing by lipid peroxidation and protects  organism  from  oxidative  stre ss induced by various toxic agents. Cadmium (Cd) is a commonly occurring environmental contaminant which after being absorbed into the organism accumulates   mostly   in  the  liver  and   kidneys .
PB  - International Coenzyme Q10 Association
C3  - Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
T1  - The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats
SP  - 160
EP  - 162
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5935
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "Coenzyme  Q10 in  its reduced  form  (CoQ10Hz) is a  powerful  antioxidant.  As  an ant io x idant it is exploited either directly upon superoxide or indirectly on lipid radic als. CoQ:0H2 can also act  together  with  Vitamin  E by regenerating  the
active  form   from  the  tocopheroxyl  radical.  CoQ10  may  prevent  both  the initiation and propagation of lipid peroxidation , prote cts DNA from oxidation
causing by lipid peroxidation and protects  organism  from  oxidative  stre ss induced by various toxic agents. Cadmium (Cd) is a commonly occurring environmental contaminant which after being absorbed into the organism accumulates   mostly   in  the  liver  and   kidneys .",
publisher = "International Coenzyme Q10 Association",
journal = "Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany",
title = "The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats",
pages = "160-162",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5935"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2000). The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
International Coenzyme Q10 Association., 160-162.
https://hdl.handle.net/21.15107/rcub_ibiss_5935

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany. 2000;:160-162.
https://hdl.handle.net/21.15107/rcub_ibiss_5935 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats" in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany (2000):160-162,
https://hdl.handle.net/21.15107/rcub_ibiss_5935 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5934
AB  - Cadmium (Cd) is a heavy metal commonly used  in ecotoxicological studies. Cd induces oxidative damage in erythrocytes, causes loss of  membrane function by enhancing lipid peroxidation and by alteration of the antioxidant defense  system  in  erythrocytes. On  the  other  hand,  recent  studies have shown   that   coenzyme   Q10   and   vitamin   E   are   the    powerful   liposoluble antiox idants,  which  inhibit   lipid   peroxidation   and   thus  prevent   free radical mediated oxidant injuries. The aim of thi s study was to i nve stigate a possible  protective  role  of  coenzyme  Q10   (CoQ 10)   and  vitamin  E  (Vit  E)  in cadmium  induced  oxidative stress  in the blood of  rats.
PB  - International Coenzyme Q10 Association
C3  - Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
T1  - Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats
SP  - 151
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5934
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "Cadmium (Cd) is a heavy metal commonly used  in ecotoxicological studies. Cd induces oxidative damage in erythrocytes, causes loss of  membrane function by enhancing lipid peroxidation and by alteration of the antioxidant defense  system  in  erythrocytes. On  the  other  hand,  recent  studies have shown   that   coenzyme   Q10   and   vitamin   E   are   the    powerful   liposoluble antiox idants,  which  inhibit   lipid   peroxidation   and   thus  prevent   free radical mediated oxidant injuries. The aim of thi s study was to i nve stigate a possible  protective  role  of  coenzyme  Q10   (CoQ 10)   and  vitamin  E  (Vit  E)  in cadmium  induced  oxidative stress  in the blood of  rats.",
publisher = "International Coenzyme Q10 Association",
journal = "Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany",
title = "Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats",
pages = "151-153",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5934"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š., Saičić, Z.,& Petrović, V. M.. (2000). Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
International Coenzyme Q10 Association., 151-153.
https://hdl.handle.net/21.15107/rcub_ibiss_5934

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z, Petrović VM. Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany. 2000;:151-153.
https://hdl.handle.net/21.15107/rcub_ibiss_5934 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Petrović, Vojislav M., "Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats" in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany (2000):151-153,
https://hdl.handle.net/21.15107/rcub_ibiss_5934 .